Literature DB >> 23223548

Organometallic anticancer agents that interfere with cellular energy processes: a subtle approach to inducing cancer cell death.

Alexey A Nazarov1, Daniel Gardini, Mathurin Baquié, Lucienne Juillerat-Jeanneret, Tatiana P Serkova, Elena P Shevtsova, Rosario Scopelliti, Paul J Dyson.   

Abstract

Two hybrid compounds comprising an antimetastatic ruthenium-arene fragment tethered to an indazole-3-carboxylic acid derivative that inhibits aerobic glycolysis in cancer cells have been prepared and evaluated in a variety of cancer cell lines, including highly relevant human glioblastoma cells, with an apparent synergistic action between the two components observed.

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Year:  2012        PMID： 23223548     DOI： 10.1039/c2dt31936e

Source DB:  PubMed          Journal:  Dalton Trans        ISSN： 1477-9226            Impact factor:   4.390


  5 in total

1.  Understanding the interactions of diruthenium anticancer agents with amino acids.

Authors:  Alexey A Nazarov; Maria-Grazia Mendoza-Ferri; Muhammad Hanif; Bernhard K Keppler; Paul J Dyson; Christian G Hartinger
Journal:  J Biol Inorg Chem       Date:  2018-07-25       Impact factor: 3.358

2.  Dimethyl Sulfoxide: A Bio-Friendly or Bio-Hazard Chemical? The Effect of DMSO in Human Fibroblast-like Synoviocytes.

Authors:  Manuel Gallardo-Villagrán; Lucie Paulus; David Yannick Leger; Bruno Therrien; Bertrand Liagre
Journal:  Molecules       Date:  2022-07-13       Impact factor: 4.927

3.  X-ray Structure Analysis of Indazolium trans-[Tetrachlorobis(1H-indazole)ruthenate(III)] (KP1019) Bound to Human Serum Albumin Reveals Two Ruthenium Binding Sites and Provides Insights into the Drug Binding Mechanism.

Authors:  Aleksandar Bijelic; Sarah Theiner; Bernhard K Keppler; Annette Rompel
Journal:  J Med Chem       Date:  2016-06-07       Impact factor: 7.446

4.  Organometallic Half-Sandwich Dichloridoruthenium(II) Complexes with 7-Azaindoles: Synthesis, Characterization and Elucidation of Their Anticancer Inactivity against A2780 Cell Line.

Authors:  Pavel Štarha; Lucie Hanousková; Zdeněk Trávníček
Journal:  PLoS One       Date:  2015-11-25       Impact factor: 3.240

5.  Ru(III) Complexes with Lonidamine-Modified Ligands.

Authors:  Ilya A Shutkov; Yulia N Okulova; Vladimir Yu Tyurin; Elena V Sokolova; Denis A Babkov; Alexander A Spasov; Yulia A Gracheva; Claudia Schmidt; Kirill I Kirsanov; Alexander A Shtil; Olga M Redkozubova; Elena F Shevtsova; Elena R Milaeva; Ingo Ott; Alexey A Nazarov
Journal:  Int J Mol Sci       Date:  2021-12-15       Impact factor: 5.923
  5 in total

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