Literature DB >> 23223235

Extracellular signal-regulated kinase 5 (ERK5) mediates prolactin-stimulated adult neurogenesis in the subventricular zone and olfactory bulb.

Wenbin Wang1, Yung-Wei Pan, Tomasz Wietecha, Junhui Zou, Glen M Abel, Chay T Kuo, Zhengui Xia.   

Abstract

Prolactin-stimulated adult neurogenesis in the subventricular zone (SVZ) and olfactory bulb (OB) mediates several reproductive behaviors including mating/pregnancy, dominant male pheromone preference in females, and paternal recognition of offspring. However, downstream signaling mechanisms underlying prolactin-induced adult neurogenesis are completely unknown. We report here for the first time that prolactin activates extracellular signal-regulated kinase 5 (ERK5), a MAP kinase that is specifically expressed in the neurogenic regions of the adult mouse brain. Knockdown of ERK5 by retroviral infection of shRNA attenuates prolactin-stimulated neurogenesis in SVZ-derived adult neural stem/progenitor cells (aNPCs). Inducible erk5 deletion in adult neural stem cells of transgenic mice inhibits neurogenesis in the SVZ and OB following prolactin infusion or mating/pregnancy. These results identify ERK5 as a novel and critical signaling mechanism underlying prolactin-induced adult neurogenesis.

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Year:  2012        PMID： 23223235      PMCID： PMC3554929          DOI： 10.1074/jbc.M112.401091

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  36 in total

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Journal:  Methods Enzymol       Date:  2006       Impact factor: 1.600

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Journal:  Proc Natl Acad Sci U S A       Date:  2006-06-09       Impact factor: 11.205

4.  Stat5a is mandatory for adult mammary gland development and lactogenesis.

Authors:  X Liu; G W Robinson; K U Wagner; L Garrett; A Wynshaw-Boris; L Hennighausen
Journal:  Genes Dev       Date:  1997-01-15       Impact factor: 11.361

5.  Brain-derived neurotrophic factor activates ERK5 in cortical neurons via a Rap1-MEKK2 signaling cascade.

Authors:  Yupeng Wang; Bing Su; Zhengui Xia
Journal:  J Biol Chem       Date:  2006-09-26       Impact factor: 5.157

Review 6.  Activation of mitogen-activated protein kinase pathways by the granulocyte colony-stimulating factor receptor: mechanisms and functional consequences.

Authors:  Tulene S Kendrick; Marie A Bogoyevitch
Journal:  Front Biosci       Date:  2007-01-01

7.  Primary structure of BMK1: a new mammalian map kinase.

Authors:  J D Lee; R J Ulevitch; J Han
Journal:  Biochem Biophys Res Commun       Date:  1995-08-15       Impact factor: 3.575

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Authors:  G Zhou; Z Q Bao; J E Dixon
Journal:  J Biol Chem       Date:  1995-05-26       Impact factor: 5.157

9.  Bmk1/Erk5 is required for cell proliferation induced by epidermal growth factor.

Authors:  Y Kato; R I Tapping; S Huang; M H Watson; R J Ulevitch; J D Lee
Journal:  Nature       Date:  1998-10-15       Impact factor: 49.962

10.  Isolation of MEK5 and differential expression of alternatively spliced forms.

Authors:  J M English; C A Vanderbilt; S Xu; S Marcus; M H Cobb
Journal:  J Biol Chem       Date:  1995-12-01       Impact factor: 5.157
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  18 in total

1.  Inducible activation of ERK5 MAP kinase enhances adult neurogenesis in the olfactory bulb and improves olfactory function.

Authors:  Wenbin Wang; Song Lu; Tan Li; Yung-Wei Pan; Junhui Zou; Glen M Abel; Lihong Xu; Daniel R Storm; Zhengui Xia
Journal:  J Neurosci       Date:  2015-05-20       Impact factor: 6.167

2.  Genetic activation of ERK5 MAP kinase enhances adult neurogenesis and extends hippocampus-dependent long-term memory.

Authors:  Wenbin Wang; Yung-Wei Pan; Junhui Zou; Tan Li; Glen M Abel; Richard D Palmiter; Daniel R Storm; Zhengui Xia
Journal:  J Neurosci       Date:  2014-02-05       Impact factor: 6.167

3.  The MAPK ERK5, but not ERK1/2, inhibits the progression of monocytic phenotype to the functioning macrophage.

Authors:  Xuening Wang; Stella Pesakhov; Jonathan S Harrison; Michael Kafka; Michael Danilenko; George P Studzinski
Journal:  Exp Cell Res       Date:  2014-10-16       Impact factor: 3.905

4.  Role of adult neurogenesis in hippocampus-dependent memory, contextual fear extinction and remote contextual memory: new insights from ERK5 MAP kinase.

Authors:  Yung-Wei Pan; Daniel R Storm; Zhengui Xia
Journal:  Neurobiol Learn Mem       Date:  2013-07-18       Impact factor: 2.877

5.  Extracellular signal-regulated kinase 5 promotes acute cellular and systemic inflammation.

Authors:  Kevin Wilhelmsen; Fengyun Xu; Katherine Farrar; Alphonso Tran; Samira Khakpour; Shirin Sundar; Arun Prakash; Jinhua Wang; Nathanael S Gray; Judith Hellman
Journal:  Sci Signal       Date:  2015-08-25       Impact factor: 8.192

6.  ERK5/KLF4 signaling as a common mediator of the neuroprotective effects of both nerve growth factor and hydrogen peroxide preconditioning.

Authors:  Chang Su; Fen Sun; Rebecca L Cunningham; Nataliya Rybalchenko; Meharvan Singh
Journal:  Age (Dordr)       Date:  2014-07-12

7.  A hydroxylated metabolite of flame-retardant PBDE-47 decreases the survival, proliferation, and neuronal differentiation of primary cultured adult neural stem cells and interferes with signaling of ERK5 MAP kinase and neurotrophin 3.

Authors:  Tan Li; Wenbin Wang; Yung-Wei Pan; Lihong Xu; Zhengui Xia
Journal:  Toxicol Sci       Date:  2013-04-05       Impact factor: 4.849

Review 8.  Detrimental role of prolonged sleep deprivation on adult neurogenesis.

Authors:  Carina Fernandes; Nuno Barbosa F Rocha; Susana Rocha; Andrea Herrera-Solís; José Salas-Pacheco; Fabio García-García; Eric Murillo-Rodríguez; Ti-Fei Yuan; Sergio Machado; Oscar Arias-Carrión
Journal:  Front Cell Neurosci       Date:  2015-04-14       Impact factor: 5.505

9.  Conditional Inhibition of Adult Neurogenesis by Inducible and Targeted Deletion of ERK5 MAP Kinase Is Not Associated with Anxiety/Depression-Like Behaviors

Authors:  Junhui Zou; Wenbin Wang; Yung-Wei Pan; Glen M Abel; Daniel R Storm; Zhengui Xia
Journal:  eNeuro       Date:  2015-04-16

10.  Targeted deletion of the ERK5 MAP kinase impairs neuronal differentiation, migration, and survival during adult neurogenesis in the olfactory bulb.

Authors:  Tan Li; Yung-Wei Pan; Wenbin Wang; Glen Abel; Junhui Zou; Lihong Xu; Daniel R Storm; Zhengui Xia
Journal:  PLoS One       Date:  2013-04-22       Impact factor: 3.240
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