Liang-Jen Wang1, Yu-Shu Huang2,3, Cheng-Cheng Hsiao4, Chih-Ken Chen3,5. 1. 1 Department of Child and Adolescent Psychiatry, Chang Gung Memorial Hospital - Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan. 2. 2 Department of Child Psychiatry and Sleep center, Chang Gung Memorial Hospital at Linko, Taoyuan, Taiwan. 3. 3 Chang Gung University School of Medicine, Taoyuan, Taiwan. 4. 4 Department of Psychiatry, Chia-Yi Christian Hospital, Chiayi, Taiwan. 5. 5 Department of Psychiatry, Chang Gung Memorial Hospital at Keelung, Taiwan.
Abstract
OBJECTIVE: To determine the trend in cortisol levels in children with ADHD treated with methylphenidate (MPH) and nontreated healthy controls over a 6-month period. METHOD: The morning salivary cortisol levels of 50 patients with ADHD (40 boys and 10 girls, mean age = 7.6 years) and 50 age- and gender-matched healthy controls were measured at baseline and at 1, 3, and 6 months from baseline. The neuropsychological performance of the ADHD patients was measured via administration of the Continuous Performance Test. RESULTS: The cortisol levels of ADHD patients increased significantly after 1 month of MPH treatment before decreasing to an intermediate level, but were significantly positively correlated with neuropsychological performance throughout the 6-month treatment period. The cortisol levels of the controls did not change significantly over the 6-month period. CONCLUSION: MPH administration appears to positively influence the functioning of the hypothalamic-pituitary-adrenal axis in ADHD patients.
OBJECTIVE: To determine the trend in cortisol levels in children with ADHD treated with methylphenidate (MPH) and nontreated healthy controls over a 6-month period. METHOD: The morning salivary cortisol levels of 50 patients with ADHD (40 boys and 10 girls, mean age = 7.6 years) and 50 age- and gender-matched healthy controls were measured at baseline and at 1, 3, and 6 months from baseline. The neuropsychological performance of the ADHDpatients was measured via administration of the Continuous Performance Test. RESULTS: The cortisol levels of ADHDpatients increased significantly after 1 month of MPH treatment before decreasing to an intermediate level, but were significantly positively correlated with neuropsychological performance throughout the 6-month treatment period. The cortisol levels of the controls did not change significantly over the 6-month period. CONCLUSION:MPH administration appears to positively influence the functioning of the hypothalamic-pituitary-adrenal axis in ADHDpatients.
Authors: Pin-Han Peng; Meng-Yun Tsai; Sheng-Yu Lee; Po-Cheng Liao; Yu-Chiau Shyu; Liang-Jen Wang Journal: Int J Environ Res Public Health Date: 2020-05-25 Impact factor: 3.390