Chaonan Fan1, Hylde Zirpoli, Kemin Qi. 1. Key Laboratory of Major Disease in Children and National Key Discipline of Pediatrics (Capital Medical University), Ministry of Education, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, Beijing, China.
Abstract
PURPOSE OF REVIEW: Dietary n-3 polyunsaturated fatty acids (n-3 PUFAs) may be related to a number of chronic metabolic abnormalities, including metabolic syndrome. This review presents an update on the effects of n-3 PUFAs on risk factors of metabolic syndrome, especially adipose tissue inflammation, oxidative stress and underlying mechanisms of these effects. RECENT FINDINGS: Anti-inflammatory actions of n-3 PUFAs are thought to be mediated by the formation of their active metabolites (eicosanoids and other lipid mediators) as well as their regulation of the production of inflammatory mediators (e.g., adipocytokines, cytokines) and immune cell infiltration into adipose tissue. n-3 PUFAs mediate these effects by modulating several pathways, such as those involving nuclear factor-κB, peroxisome proliferator-activated receptors and Toll-like receptors. The antioxidative effects of n-3 PUFAs in adipocytes appear to inhibit reactive oxygen species production and alter mitochondrial function. SUMMARY: This review summarizes the evidence for beneficial effects of n-3 PUFAs on adipose tissue inflammation and oxidative stress. More studies are necessary to investigate the mechanisms underlying these effects and to relate this topic to human health.
PURPOSE OF REVIEW: Dietary n-3 polyunsaturated fatty acids (n-3 PUFAs) may be related to a number of chronic metabolic abnormalities, including metabolic syndrome. This review presents an update on the effects of n-3 PUFAs on risk factors of metabolic syndrome, especially adipose tissue inflammation, oxidative stress and underlying mechanisms of these effects. RECENT FINDINGS: Anti-inflammatory actions of n-3 PUFAs are thought to be mediated by the formation of their active metabolites (eicosanoids and other lipid mediators) as well as their regulation of the production of inflammatory mediators (e.g., adipocytokines, cytokines) and immune cell infiltration into adipose tissue. n-3 PUFAs mediate these effects by modulating several pathways, such as those involving nuclear factor-κB, peroxisome proliferator-activated receptors and Toll-like receptors. The antioxidative effects of n-3 PUFAs in adipocytes appear to inhibit reactive oxygen species production and alter mitochondrial function. SUMMARY: This review summarizes the evidence for beneficial effects of n-3 PUFAs on adipose tissue inflammation and oxidative stress. More studies are necessary to investigate the mechanisms underlying these effects and to relate this topic to human health.
Authors: Yuriko Adkins; Benjamin J Belda; Theresa L Pedersen; Dawn M Fedor; Bruce E Mackey; John W Newman; Darshan S Kelley Journal: Lipids Date: 2017-04-13 Impact factor: 1.880
Authors: Dominik D Alexander; Julie K Bassett; Douglas L Weed; Erin Cernkovich Barrett; Heather Watson; William Harris Journal: Nutr Cancer Date: 2015-03-31 Impact factor: 2.900