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Literature DB >> 23221569

Molecular mechanism behind rotavirus NSP1-mediated PI3 kinase activation: interaction between NSP1 and the p85 subunit of PI3 kinase.

Parikshit Bagchi¹, Satabdi Nandi, Mukti Kant Nayak, Mamta Chawla-Sarkar.

Abstract

Our previous study had reported on the interaction of rotavirus NSP1 with cellular phosphoinositide 3-kinase (PI3K) during activation of the PI3K pathway (P. Bagchi et al., J. Virol. 84:6834-6845, 2010). In this study, we have analyzed the molecular mechanism behind this interaction. Results showed that this interaction is direct and that both α and β isomers of the PI3K regulatory subunit p85 and full-length NSP1 are important for this interaction, which results in efficient activation of the PI3K/Akt pathway during rotavirus infection.

Entities: Disease Gene

Mesh：

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Year: 2012 PMID： 23221569 PMCID： PMC3571490 DOI： 10.1128/JVI.02479-12

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

14 in total

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