Literature DB >> 23221478

Successful TRPV1 antagonist treatment for cardiac hypertrophy and heart failure in mice.

Jaime S Horton1, Cadie L Buckley, Alexander J Stokes.   

Abstract

Heart failure is becoming a global epidemic. It exerts a staggering toll on quality of life, and substantial medical and economic impact. In a pre-clinical model of cardiac hypertrophy and heart failure, we were able to overcome loss of heart function by administering the TRPV1 antagonist BCTC (4-(3-Chloro-2-pyridinyl)-N-[4-(1,1-dimethylethyl)phenyl]-1-piperazinecarboxamide). The results presented here identify TRPV1 antagonists as new treatment options for cardiac hypertrophy and heart failure.

Entities:  

Keywords:  TRPV1; apoptosis; cardiac hypertrophy; fibrosis; heart failure; pressure overload

Mesh：

Substances：

Year:  2012        PMID： 23221478      PMCID： PMC3589277          DOI： 10.4161/chan.23006

Source DB:  PubMed          Journal:  Channels (Austin)        ISSN： 1933-6950            Impact factor:   2.581


  27 in total

1.  Role of TRPV1 and intracellular Ca2+ in excitation of cardiac sensory neurons by bradykinin.

Authors:  Zi-Zhen Wu; Hui-Lin Pan
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2007-05-09       Impact factor: 3.619

Review 2.  Mechanosensitive TRP channels in cardiovascular pathophysiology.

Authors:  Ryuji Inoue; Zhong Jian; Yasuhiro Kawarabayashi
Journal:  Pharmacol Ther       Date:  2009-06-06       Impact factor: 12.310

3.  Influence of ejection fraction on cardiovascular outcomes in a broad spectrum of heart failure patients.

Authors:  Scott D Solomon; Nagesh Anavekar; Hicham Skali; John J V McMurray; Karl Swedberg; Salim Yusuf; Christopher B Granger; Eric L Michelson; Duolao Wang; Stuart Pocock; Marc A Pfeffer
Journal:  Circulation       Date:  2005-12-05       Impact factor: 29.690

Review 4.  Molecular basis of cardiac hypertrophy.

Authors:  T Yamazaki; Y Yazaki
Journal:  Z Kardiol       Date:  2000-01

5.  TRPV1 gene knockout impairs postischemic recovery in isolated perfused heart in mice.

Authors:  Lihong Wang; Donna H Wang
Journal:  Circulation       Date:  2005-11-28       Impact factor: 29.690

6.  Prognostic value of exercise 201Tl tomography in patients treated with thrombolytic therapy during acute myocardial infarction.

Authors:  H A Dakik; J J Mahmarian; K T Kimball; M G Koutelou; R Medrano; M S Verani
Journal:  Circulation       Date:  1996-12-01       Impact factor: 29.690

7.  N-(4-tertiarybutylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: I. in vitro characterization and pharmacokinetic properties.

Authors:  Kenneth J Valenzano; Elfrida R Grant; Gang Wu; Mohamed Hachicha; Lori Schmid; Laykea Tafesse; Qun Sun; Yakov Rotshteyn; Joseph Francis; James Limberis; Shiazah Malik; Edward R Whittemore; Dianne Hodges
Journal:  J Pharmacol Exp Ther       Date:  2003-04-29       Impact factor: 4.030

8.  A role for cardiac mast cells in the pathogenesis of hypertensive heart disease.

Authors:  Naotaka Shiota; Jaana Rysä; Petri T Kovanen; Heikki Ruskoaho; Jorma O Kokkonen; Ken A Lindstedt
Journal:  J Hypertens       Date:  2003-10       Impact factor: 4.844

9.  Sensing tissue ischemia: another new function for capsaicin receptors?

Authors:  Hui-Lin Pan; Shao-Rui Chen
Journal:  Circulation       Date:  2004-09-13       Impact factor: 29.690

10.  Segregation of atrial-specific and inducible expression of an atrial natriuretic factor transgene in an in vivo murine model of cardiac hypertrophy.

Authors:  H A Rockman; R S Ross; A N Harris; K U Knowlton; M E Steinhelper; L J Field; J Ross; K R Chien
Journal:  Proc Natl Acad Sci U S A       Date:  1991-09-15       Impact factor: 11.205
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  14 in total

1.  Cardiac sympathetic afferent denervation attenuates cardiac remodeling and improves cardiovascular dysfunction in rats with heart failure.

Authors:  Han-Jun Wang; Wei Wang; Kurtis G Cornish; George J Rozanski; Irving H Zucker
Journal:  Hypertension       Date:  2014-06-30       Impact factor: 10.190

2.  Medical school hotline: the research mission of the cell and molecular biology department and program at the john a. Burns school of medicine.

Authors:  Marla J Berry; Joshua Astern; Frederick Bellinger; Christopher Brampton; Rebecca Cann; Mariana Gerschenson; David Haymer; Nicholas G James; David M Jameson; Olivier LeSaux; Peter R Hoffmann; Robert Nichols; Matthew Pitts; Lucia Seale; Steven Seifried; Alexander J Stokes; Cedomir Todorovic
Journal:  Hawaii J Med Public Health       Date:  2015-04

Review 3.  Role of TRP channels in the cardiovascular system.

Authors:  Zhichao Yue; Jia Xie; Albert S Yu; Jonathan Stock; Jianyang Du; Lixia Yue
Journal:  Am J Physiol Heart Circ Physiol       Date:  2014-11-21       Impact factor: 4.733

4.  The calcium release-activated calcium channel Orai1 represents a crucial component in hypertrophic compensation and the development of dilated cardiomyopathy.

Authors:  Jaime S Horton; Cadie L Buckley; Ernest M Alvarez; Anita Schorlemmer; Alexander J Stokes
Journal:  Channels (Austin)       Date:  2013-10-17       Impact factor: 2.581

5.  Mitogen-Activated Protein Kinase and Intracellular Polyamine Signaling Is Involved in TRPV1 Activation-Induced Cardiac Hypertrophy.

Authors:  Mai Chen; Jiajia Xin; Baohui Liu; Liyang Luo; Jiayi Li; Wen Yin; Mingkai Li
Journal:  J Am Heart Assoc       Date:  2016-07-29       Impact factor: 5.501

Review 6.  Transient receptor potential channels in cardiac health and disease.

Authors:  Thomas Hof; Sébastien Chaigne; Alice Récalde; Laurent Sallé; Fabien Brette; Romain Guinamard
Journal:  Nat Rev Cardiol       Date:  2019-06       Impact factor: 32.419

Review 7.  Does Transient Receptor Potential Vanilloid Type 1 Alleviate or Aggravate Pathological Myocardial Hypertrophy?

Authors:  Qiqi Yan; Jun Tang; Xin Zhang; Liuyang Wu; Yunyi Xu; Lihong Wang
Journal:  Front Pharmacol       Date:  2021-05-10       Impact factor: 5.810

8.  Chronic ablation of TRPV1-sensitive skeletal muscle afferents attenuates the muscle metaboreflex.

Authors:  Joseph Mannozzi; Mohamed-Hussein Al-Hassan; Beruk Lessanework; Alberto Alvarez; Danielle Senador; Donal S O'Leary
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2021-07-14       Impact factor: 3.210

9.  TRPA1 is functionally co-expressed with TRPV1 in cardiac muscle: Co-localization at z-discs, costameres and intercalated discs.

Authors:  Spencer R Andrei; Pritam Sinharoy; Ian N Bratz; Derek S Damron
Journal:  Channels (Austin)       Date:  2016-05-04       Impact factor: 2.581

10.  TRPV-1-mediated elimination of residual iPS cells in bioengineered cardiac cell sheet tissues.

Authors:  Katsuhisa Matsuura; Hiroyoshi Seta; Yuji Haraguchi; Khaled Alsayegh; Hidekazu Sekine; Tatsuya Shimizu; Nobuhisa Hagiwara; Kenji Yamazaki; Teruo Okano
Journal:  Sci Rep       Date:  2016-02-18       Impact factor: 4.379
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