BACKGROUND: The in-hospital mortality of patients with acute heart failure (AHF) is reported to be 12.7% and mortality on day 30 after admission 17.2%. Less information is known about the long-term prognosis of those patients discharged after hospitalization. As such, the aim of this study was to investigate long-term survival in a cohort of patients who had been hospitalized for AHF and then discharged. METHODS: The AHEAD Main registry includes 4153 patients hospitalized for AHF in 7 different medical centers, each with its own cathlab, in the Czech Republic. Patient survival rates were evaluated in 3438 patients who had survived to day 30 after admission, and were used as a measurement of long-term survival. RESULTS: The most common etiologies were acute coronary syndrome (32.3%) and chronic ischemic heart disease (20.1%). The survival rate after day 30 following admission was 79.7% after 1 year and 64.5% after 3 years. No statistically significant difference in syndromes was found in survival after day 30. Independent predictors of a worse prognosis were defined as follows: age>70 years, comorbidities, severe left ventricular systolic dysfunction, valvular disease or ACS as an etiology of AHF. A better prognosis was defined for de-novo AHF patients, and those who were taking ACE inhibitors at the time of discharge. In a sub-analysis, high levels of natriuretic peptides were the most powerful predictors of high-risk, long-term mortality. CONCLUSION: The AHEAD Main registry provides up-to-date information on the long-term prognosis of patients hospitalized with AHF. The 3-year survival of patients following day 30 of admission was 64.5%. Higher age, LV dysfunction, comorbidities and high levels of natriuretic peptides were the most powerful predictors of worse prognosis in long-term survival.
BACKGROUND: The in-hospital mortality of patients with acute heart failure (AHF) is reported to be 12.7% and mortality on day 30 after admission 17.2%. Less information is known about the long-term prognosis of those patients discharged after hospitalization. As such, the aim of this study was to investigate long-term survival in a cohort of patients who had been hospitalized for AHF and then discharged. METHODS: The AHEAD Main registry includes 4153 patients hospitalized for AHF in 7 different medical centers, each with its own cathlab, in the Czech Republic. Patient survival rates were evaluated in 3438 patients who had survived to day 30 after admission, and were used as a measurement of long-term survival. RESULTS: The most common etiologies were acute coronary syndrome (32.3%) and chronic ischemic heart disease (20.1%). The survival rate after day 30 following admission was 79.7% after 1 year and 64.5% after 3 years. No statistically significant difference in syndromes was found in survival after day 30. Independent predictors of a worse prognosis were defined as follows: age>70 years, comorbidities, severe left ventricular systolic dysfunction, valvular disease or ACS as an etiology of AHF. A better prognosis was defined for de-novo AHF patients, and those who were taking ACE inhibitors at the time of discharge. In a sub-analysis, high levels of natriuretic peptides were the most powerful predictors of high-risk, long-term mortality. CONCLUSION: The AHEAD Main registry provides up-to-date information on the long-term prognosis of patients hospitalized with AHF. The 3-year survival of patients following day 30 of admission was 64.5%. Higher age, LV dysfunction, comorbidities and high levels of natriuretic peptides were the most powerful predictors of worse prognosis in long-term survival.
Authors: W von Scheidt; C Zugck; M Pauschinger; R Hambrecht; O Bruder; A Hartmann; M Rauchhaus; R Zahn; J Brachmann; U Tebbe; T Neumann; R H Strasser; M Böhm; S Störk; M Hochadel; P Heidemann; J Senges Journal: Clin Res Cardiol Date: 2014-07-23 Impact factor: 5.460
Authors: Ovidiu Chioncel; Sean P Collins; Stephen J Greene; Peter S Pang; Andrew P Ambrosy; Elena-Laura Antohi; Muthiah Vaduganathan; Javed Butler; Mihai Gheorghiade Journal: Card Fail Rev Date: 2017-11
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Authors: Jindrich Spinar; Jiri Jarkovsky; Lenka Spinarova; Jiri Vitovec; Ales Linhart; Petr Widimsky; Roman Miklik; Kamil Zeman; Jan Belohlavek; Filip Malek; Cestmir Cihalik; Jiri Spac; Marian Felsoci; Petr Ostadal; Ladislav Dusek; Jiri Kettner; Jan Vaclavik; Simona Littnerova; Zdeněk Monhart; Josef Malek; Jiri Parenica Journal: ESC Heart Fail Date: 2016-09-17
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Authors: Clare J Taylor; José M Ordóñez-Mena; Andrea K Roalfe; Sarah Lay-Flurrie; Nicholas R Jones; Tom Marshall; F D Richard Hobbs Journal: BMJ Date: 2019-02-13
Authors: Marie Pavlusova; Jiri Jarkovsky; Klara Benesova; Jiri Vitovec; Ales Linhart; Petr Widimsky; Lenka Spinarova; Kamil Zeman; Jan Belohlavek; Filip Malek; Marian Felsoci; Jiri Kettner; Petr Ostadal; Cestmir Cihalik; Jiri Spac; Hikmet Al-Hiti; Marian Fedorco; Richard Fojt; Andreas Kruger; Josef Malek; Tereza Mikusova; Zdenek Monhart; Stanislava Bohacova; Lidka Pohludkova; Filip Rohac; Jan Vaclavik; Dagmar Vondrakova; Klaudia Vyskocilova; Miroslav Bambuch; Gabriela Dostalova; Stepan Havranek; Ivana Svobodová; Ladislav Dusek; Jindrich Spinar; Roman Miklik; Jiri Parenica Journal: Clin Cardiol Date: 2019-05-29 Impact factor: 2.882
Authors: Hussam AlFaleh; Abdelfatah A Elasfar; Anhar Ullah; Khalid F AlHabib; Ahmad Hersi; Layth Mimish; Ali Almasood; Saleh Al Ghamdi; Abdullah Ghabashi; Asif Malik; Gamal A Hussein; Mushabab Al-Murayeh; Ahmed Abuosa; Waleed Al Habeeb; Tarek S Kashour Journal: BMC Cardiovasc Disord Date: 2016-05-20 Impact factor: 2.298
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