Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Rho GTPases and their roles in cancer metabolism.

Literature DB >> 23219172

Rho GTPases and their roles in cancer metabolism.

Kristin F Wilson¹, Jon W Erickson, Marc A Antonyak, Richard A Cerione.

Abstract

Recently, the small molecule 968 was found to block the Rho GTPase-dependent growth of cancer cells in cell culture and mouse xenografts, and when the target of 968 was found to be the mitochondrial enzyme glutaminase (GLS1), it revealed a surprising link between Rho GTPases and mitochondrial glutamine metabolism. Signal transduction via the Rho GTPases, together with NF-κB, appears to elevate mitochondrial glutaminase activity in cancer cells, thereby helping cancer cells satisfy their altered metabolic demands. Here, we review what is known about the mechanism of glutaminase activation in cancer cells, compare the properties of two distinct glutaminase inhibitors, and discuss recent findings that shed new light on how glutamine metabolism might affect cancer progression.

Entities: CellLine Chemical Disease Gene Species

Mesh：

Substances：

Year: 2012 PMID： 23219172 PMCID： PMC3607349 DOI： 10.1016/j.molmed.2012.10.011

Source DB: PubMed Journal: Trends Mol Med ISSN： 1471-4914 Impact factor: 11.951

52 in total

1. Dbl and the Rho GTPases activate NF kappa B by I kappa B kinase (IKK)-dependent and IKK-independent pathways.

Authors: M S Cammarano; A Minden
Journal: J Biol Chem Date: 2001-05-03 Impact factor: 5.157

2. Cdc42 stimulates RNA splicing via the S6 kinase and a novel S6 kinase target, the nuclear cap-binding complex.

Authors: K F Wilson; W J Wu; R A Cerione
Journal: J Biol Chem Date: 2000-12-01 Impact factor: 5.157

Review 3. Rho GTPases in cell biology.

Authors: Sandrine Etienne-Manneville; Alan Hall
Journal: Nature Date: 2002-12-12 Impact factor: 49.962

4. Endogenous, hyperactive Rac3 controls proliferation of breast cancer cells by a p21-activated kinase-dependent pathway.

Authors: J P Mira; V Benard; J Groffen; L C Sanders; U G Knaus
Journal: Proc Natl Acad Sci U S A Date: 2000-01-04 Impact factor: 11.205

5. Leukemia-associated Rho guanine nucleotide exchange factor promotes G alpha q-coupled activation of RhoA.

Authors: Michelle A Booden; David P Siderovski; Channing J Der
Journal: Mol Cell Biol Date: 2002-06 Impact factor: 4.272

6. Mutation status of genes encoding RhoA, Rac1, and Cdc42 GTPases in a panel of invasive human colorectal and breast tumors.

Authors: S Rihet; P Vielh; J Camonis; B Goud; S Chevillard; J de Gunzburg
Journal: J Cancer Res Clin Oncol Date: 2001-12 Impact factor: 4.553

7. Characterization of RhoC expression in benign and malignant breast disease: a potential new marker for small breast carcinomas with metastatic ability.

Authors: Celina G Kleer; Kenneth L van Golen; Yanhong Zhang; Zhi-Fen Wu; Mark A Rubin; Sofia D Merajver
Journal: Am J Pathol Date: 2002-02 Impact factor: 4.307

8. Bacterial expression, purification, and characterization of rat kidney-type mitochondrial glutaminase.

Authors: John Kenny; Yuhne Bao; Brian Hamm; Lynn Taylor; Ann Toth; Brian Wagers; Norman P Curthoys
Journal: Protein Expr Purif Date: 2003-09 Impact factor: 1.650

9. DLC-1 gene inhibits human breast cancer cell growth and in vivo tumorigenicity.

Authors: Bao-Zhu Yuan; Xiaoling Zhou; Marian E Durkin; Drazen B Zimonjic; Katrin Gumundsdottir; Jorunn E Eyfjord; Snorri S Thorgeirsson; Nicholas C Popescu
Journal: Oncogene Date: 2003-01-23 Impact factor: 9.867

10. Rho GTPases in human breast tumours: expression and mutation analyses and correlation with clinical parameters.

Authors: G Fritz; C Brachetti; F Bahlmann; M Schmidt; B Kaina
Journal: Br J Cancer Date: 2002-09-09 Impact factor: 7.640

41 in total

Review 1. Stress granules and cell signaling: more than just a passing phase?

Authors: Nancy Kedersha; Pavel Ivanov; Paul Anderson
Journal: Trends Biochem Sci Date: 2013-09-10 Impact factor: 13.807

2. Cdc42p-interacting protein Bem4p regulates the filamentous-growth mitogen-activated protein kinase pathway.

Authors: Andrew Pitoniak; Colin A Chavel; Jacky Chow; Jeremy Smith; Diawoye Camara; Sheelarani Karunanithi; Boyang Li; Kennith H Wolfe; Paul J Cullen
Journal: Mol Cell Biol Date: 2014-11-10 Impact factor: 4.272

3. Emergent membrane morphologies in relaxed and tense membranes in presence of reversible adhesive pinning interactions.

Authors: Sreeja Kutti Kandy; Ravi Radhakrishnan
Journal: Phys Biol Date: 2019-10-21 Impact factor: 2.583

4. Glutamine metabolism via glutaminase 1 in autosomal-dominant polycystic kidney disease.

Authors: Irfana Soomro; Ying Sun; Zhai Li; Lonnette Diggs; Georgia Hatzivassiliou; Ajit G Thomas; Rana Rais; Seth J Parker; Barbara S Slusher; Alec C Kimmelman; Stefan Somlo; Edward Y Skolnik
Journal: Nephrol Dial Transplant Date: 2018-08-01 Impact factor: 5.992

5. Identification of cancer driver genes based on nucleotide context.

Authors: Felix Dietlein; Donate Weghorn; Amaro Taylor-Weiner; André Richters; Brendan Reardon; David Liu; Eric S Lander; Eliezer M Van Allen; Shamil R Sunyaev
Journal: Nat Genet Date: 2020-02-03 Impact factor: 38.330

6. Rac1 GTPase-deficient HeLa cells present reduced DNA repair, proliferation, and survival under UV or gamma irradiation.

Authors: Gisele Espinha; Juliana H Osaki; Yuli T Magalhaes; Fabio Luis Forti
Journal: Mol Cell Biochem Date: 2015-03-11 Impact factor: 3.396

7. ERG oncoprotein inhibits ANXA2 expression and function in prostate cancer.

Authors: Nicholas B Griner; Denise Young; Pankaj Chaudhary; Ahmed A Mohamed; Wei Huang; Yongmei Chen; Taduru Sreenath; Albert Dobi; Gyorgy Petrovics; Jamboor K Vishwanatha; Isabell A Sesterhenn; Shiv Srivastava; Shyh-Han Tan
Journal: Mol Cancer Res Date: 2014-10-24 Impact factor: 5.852