Literature DB >> 23218779

Carbohydrate-conjugated porphyrin dimers: synthesis and photobiological evaluation for a potential application in one-photon and two-photon photodynamic therapy.

Guillaume Garcia1, Fabien Hammerer, Florent Poyer, Sylvain Achelle, Marie-Paule Teulade-Fichou, Philippe Maillard.   

Abstract

We report the synthesis of bioconjugated zinc porphyrin dimers 1a-e designed as photosensitizers for one-photon and two-photon excited photodynamic therapy. These macrocycles are substituted with carbohydrate units (glucose, mannose, lactose) in order to target tumor cells over-expressing lectin membrane receptors. Polarity, singlet oxygen production and in vitro photocytotoxicity are studied to determine their photodynamic therapy potentiality.
Copyright © 2012 Elsevier Ltd. All rights reserved.

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Year:  2012        PMID： 23218779     DOI： 10.1016/j.bmc.2012.10.042

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  5 in total

Review 1.  Glycosylated Porphyrins, Phthalocyanines, and Other Porphyrinoids for Diagnostics and Therapeutics.

Authors:  Sunaina Singh; Amit Aggarwal; N V S Dinesh K Bhupathiraju; Gianluca Arianna; Kirran Tiwari; Charles Michael Drain
Journal:  Chem Rev       Date:  2015-08-28       Impact factor: 60.622

2.  Photophysics of glycosylated derivatives of a chlorin, isobacteriochlorin and bacteriochlorin for photodynamic theragnostics: discovery of a two-photon-absorbing photosensitizer.

Authors:  Amit Aggarwal; Sebastian Thompson; Sunaina Singh; Brandon Newton; Akeem Moore; Ruomie Gao; Xinbin Gu; Sushmita Mukherjee; Charles Michael Drain
Journal:  Photochem Photobiol       Date:  2013-11-28       Impact factor: 3.421

3.  Maltotriose Conjugated Metal-Organic Frameworks for Selective Targeting and Photodynamic Therapy of Triple Negative Breast Cancer Cells and Tumor Associated Macrophages.

Authors:  Yoshie Sakamaki; John Ozdemir; Alda Diaz Perez; Zachary Heidrick; Olivia Watson; Miu Tsuji; Chirstopher Salmon; Joseph Batta-Mpouma; Anthony Azzun; Valerie Lomonte; Yuchun Du; Julie Stenken; Jin Woo-Kim; M Hassan Beyzavi
Journal:  Adv Ther (Weinh)       Date:  2020-06-08

4.  Multifunctional Phosphorescent Conjugated Polymer Dots for Hypoxia Imaging and Photodynamic Therapy of Cancer Cells.

Authors:  Xiaobo Zhou; Hua Liang; Pengfei Jiang; Kenneth Yin Zhang; Shujuan Liu; Tianshe Yang; Qiang Zhao; Lijuan Yang; Wen Lv; Qi Yu; Wei Huang
Journal:  Adv Sci (Weinh)       Date:  2015-09-10       Impact factor: 16.806

5.  A Bio-Conjugated Chlorin-Based Metal-Organic Framework for Targeted Photodynamic Therapy of Triple Negative Breast and Pancreatic Cancers.

Authors:  Yoshie Sakamaki; John Ozdemir; Zachary Heidrick; Anthony Azzun; Olivia Watson; Miu Tsuji; Christopher Salmon; Arvind Sinha; Joseph Batta-Mpouma; Zachary McConnell; David Fugitt; Yuchun Du; Jin-Woo Kim; Hudson Beyzavi
Journal:  ACS Appl Bio Mater       Date:  2021-01-28
  5 in total

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