PURPOSE: To assess the symmetry of optic nerve head parameters measured by the Heidelberg Retina Tomograph 3 (HRT 3) between fellow eyes in a normal elderly population. DESIGN: Cross-sectional population-based study. METHODS: Participants of the Blue Mountains Eye Study 10-year follow-up who did not have optic disc disease, including glaucoma, were included. Optic nerve head parameters measured by HRT 3 were compared between fellow eyes. The normal range of interocular asymmetry (larger disc minus smaller disc) was determined by the 2.5th and 97.5th percentiles. RESULTS: A total of 1276 eligible participants had HRT scans of both eyes. HRT measurements in right eyes differed slightly in rim steepness and rim volume from those in left eyes (P < .05). The 2.5th and 97.5th percentile of interocular asymmetry limits were -0.41 and 0.45 for cup-to-disc ratio and -0.19 and 0.22 for cup-to-disc area ratio, respectively. The highest interocular correlation was found in disc area and cup area (r ranged from 0.74-0.76), whereas mean cup depth, cup volume, and retinal nerve fiber layer thickness had the poorest correlation (r ≤ 0.07). Greater optic disc area asymmetry was associated with a larger interocular difference in the other optic nerve head parameters. CONCLUSIONS: There was minimal interocular difference and substantial interocular correlation in optic nerve head parameters measured by HRT 3. Interocular asymmetry greater than 0.2 for cup-to-disc area ratio was considered outside the normal range.
PURPOSE: To assess the symmetry of optic nerve head parameters measured by the Heidelberg Retina Tomograph 3 (HRT 3) between fellow eyes in a normal elderly population. DESIGN: Cross-sectional population-based study. METHODS:Participants of the Blue Mountains Eye Study 10-year follow-up who did not have optic disc disease, including glaucoma, were included. Optic nerve head parameters measured by HRT 3 were compared between fellow eyes. The normal range of interocular asymmetry (larger disc minus smaller disc) was determined by the 2.5th and 97.5th percentiles. RESULTS: A total of 1276 eligible participants had HRT scans of both eyes. HRT measurements in right eyes differed slightly in rim steepness and rim volume from those in left eyes (P < .05). The 2.5th and 97.5th percentile of interocular asymmetry limits were -0.41 and 0.45 for cup-to-disc ratio and -0.19 and 0.22 for cup-to-disc area ratio, respectively. The highest interocular correlation was found in disc area and cup area (r ranged from 0.74-0.76), whereas mean cup depth, cup volume, and retinal nerve fiber layer thickness had the poorest correlation (r ≤ 0.07). Greater optic disc area asymmetry was associated with a larger interocular difference in the other optic nerve head parameters. CONCLUSIONS: There was minimal interocular difference and substantial interocular correlation in optic nerve head parameters measured by HRT 3. Interocular asymmetry greater than 0.2 for cup-to-disc area ratio was considered outside the normal range.
Authors: Kendall W Wannamaker; Sarah Kenny; Rishi Das; Aaron Mendlovitz; Jordan M Comstock; Edward R Chu; Sepehr Bahadorani; Nathan J Gresores; Kinley D Beck; Chelsey J Krambeer; Daniel S Kermany; Roberto Diaz-Rohena; Daniel P Nolan; Jeong-Hyeon Sohn; Michael A Singer Journal: Clin Ophthalmol Date: 2019-06-27
Authors: Henriët Springelkamp; René Höhn; Aniket Mishra; Pirro G Hysi; Chiea-Chuen Khor; Stephanie J Loomis; Jessica N Cooke Bailey; Jane Gibson; Gudmar Thorleifsson; Sarah F Janssen; Xiaoyan Luo; Wishal D Ramdas; Eranga Vithana; Monisha E Nongpiur; Grant W Montgomery; Liang Xu; Jenny E Mountain; Puya Gharahkhani; Yi Lu; Najaf Amin; Lennart C Karssen; Kar-Seng Sim; Elisabeth M van Leeuwen; Adriana I Iglesias; Virginie J M Verhoeven; Michael A Hauser; Seng-Chee Loon; Dominiek D G Despriet; Abhishek Nag; Cristina Venturini; Paul G Sanfilippo; Arne Schillert; Jae H Kang; John Landers; Fridbert Jonasson; Angela J Cree; Leonieke M E van Koolwijk; Fernando Rivadeneira; Emmanuelle Souzeau; Vesteinn Jonsson; Geeta Menon; Robert N Weinreb; Paulus T V M de Jong; Ben A Oostra; André G Uitterlinden; Albert Hofman; Sarah Ennis; Unnur Thorsteinsdottir; Kathryn P Burdon; Timothy D Spector; Alireza Mirshahi; Seang-Mei Saw; Johannes R Vingerling; Yik-Ying Teo; Jonathan L Haines; Roger C W Wolfs; Hans G Lemij; E-Shyong Tai; Nomdo M Jansonius; Jost B Jonas; Ching-Yu Cheng; Tin Aung; Ananth C Viswanathan; Caroline C W Klaver; Jamie E Craig; Stuart Macgregor; David A Mackey; Andrew J Lotery; Kari Stefansson; Arthur A B Bergen; Terri L Young; Janey L Wiggs; Norbert Pfeiffer; Tien-Yin Wong; Louis R Pasquale; Alex W Hewitt; Cornelia M van Duijn; Christopher J Hammond Journal: Nat Commun Date: 2014-09-22 Impact factor: 14.919