PURPOSE: This study aimed to analyze the impact of age at Kasai operation on the short-term outcome of type III biliary atresia (BA) and to discuss if pathological scoring can be the prediction of effect in the Kasai procedure for the older (≥ 90 days) infant. METHODS: During the period 2004 through 2010, 452 infants with type III BA were reviewed. The relationship between ages at Kasai operation and jaundice clearance rates and two year native liver survival rates were assessed, retrospectively. Pathological slides were analyzed with a histological scoring system. RESULTS: All of the patients were divided into 3 groups according to their ages at operation (group A: aged 60 days or less (n=146), group B: age between 60 and 90 days (n=222) , and group C: age on or over 90 days (n=84)). The worst outcome of clearance of jaundice was found in group A but not in group C 2 weeks after the operation (P<0.05). Jaundice clearance rates showed no difference among the three groups either at 3-months or 6-months after operation. Moreover, in group C patients, the pathological scores showed no difference between the jaundice clearance group and jaundice persistence group 6 months after surgery. In group C, two year survival rate of patients with native livers was 36.1%. CONCLUSION: Some patients over 90 days of age at surgery can still benefit from a Kasai procedure. The pathological scoring system does not play a role in predicting jaundice clearance in patients over 90 days of age at surgery. Crown
PURPOSE: This study aimed to analyze the impact of age at Kasai operation on the short-term outcome of type III biliary atresia (BA) and to discuss if pathological scoring can be the prediction of effect in the Kasai procedure for the older (≥ 90 days) infant. METHODS: During the period 2004 through 2010, 452 infants with type III BA were reviewed. The relationship between ages at Kasai operation and jaundice clearance rates and two year native liver survival rates were assessed, retrospectively. Pathological slides were analyzed with a histological scoring system. RESULTS: All of the patients were divided into 3 groups according to their ages at operation (group A: aged 60 days or less (n=146), group B: age between 60 and 90 days (n=222) , and group C: age on or over 90 days (n=84)). The worst outcome of clearance of jaundice was found in group A but not in group C 2 weeks after the operation (P<0.05). Jaundice clearance rates showed no difference among the three groups either at 3-months or 6-months after operation. Moreover, in group C patients, the pathological scores showed no difference between the jaundice clearance group and jaundice persistence group 6 months after surgery. In group C, two year survival rate of patients with native livers was 36.1%. CONCLUSION: Some patients over 90 days of age at surgery can still benefit from a Kasai procedure. The pathological scoring system does not play a role in predicting jaundice clearance in patients over 90 days of age at surgery. Crown
Authors: Kevin E Bove; Andrew D Thrasher; Robert Anders; Catherine T Chung; Oscar W Cummings; Milton J Finegold; Laura Finn; Sarangarajan Ranganathan; Grace E Kim; Mark Lovell; Margret S Magid; Hector Melin-Aldana; Pierre Russo; Bahig Shehata; Larry Wang; Francis White; Zhen Chen; Catherine Spino; John C Magee Journal: Am J Surg Pathol Date: 2018-12 Impact factor: 6.394
Authors: Chen Zhen; Qiao Guoliang; Ma Lishuang; Zhang Zhen; Wang Chen; Zhang Jun; Liu Shuli; Guan Kaoping; Liu Chao; Yang Xuan; Li Long Journal: Pediatr Surg Int Date: 2015-04-18 Impact factor: 1.827
Authors: Zheng Qipeng; Yang Fang; Zhao Yilin; Liu Gengxin; Li Mengdi; Hu Xiaoli; Zhan Jianghua Journal: Pediatr Surg Int Date: 2021-10-07 Impact factor: 1.827