Literature DB >> 23217699

SIRT6 puts cancer metabolism in the driver's seat.

Costas A Lyssiotis1, Lewis C Cantley.   

Abstract

The rewiring of metabolism in cancer is thought to result from hyperactivation of signaling pathways that instruct cells to grow. Sebastian et al. show that loss of the tumor suppressor SIRT6 transforms cells by activating tumor metabolism. This occurs independently of mutations in canonical growth signaling pathways and reveals a tumorigenic role for cancer metabolism.
Copyright © 2012 Elsevier Inc. All rights reserved.

Entities:  

Year:  2012        PMID： 23217699      PMCID： PMC3757516          DOI： 10.1016/j.cell.2012.11.020

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  10 in total

1.  Genomic instability and aging-like phenotype in the absence of mammalian SIRT6.

Authors:  Raul Mostoslavsky; Katrin F Chua; David B Lombard; Wendy W Pang; Miriam R Fischer; Lionel Gellon; Pingfang Liu; Gustavo Mostoslavsky; Sonia Franco; Michael M Murphy; Kevin D Mills; Parin Patel; Joyce T Hsu; Andrew L Hong; Ethan Ford; Hwei-Ling Cheng; Caitlin Kennedy; Nomeli Nunez; Roderick Bronson; David Frendewey; Wojtek Auerbach; David Valenzuela; Margaret Karow; Michael O Hottiger; Stephen Hursting; J Carl Barrett; Leonard Guarente; Richard Mulligan; Bruce Demple; George D Yancopoulos; Frederick W Alt
Journal:  Cell       Date:  2006-01-27       Impact factor: 41.582

2.  Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction.

Authors:  David R Wise; Ralph J DeBerardinis; Anthony Mancuso; Nabil Sayed; Xiao-Yong Zhang; Harla K Pfeiffer; Ilana Nissim; Evgueni Daikhin; Marc Yudkoff; Steven B McMahon; Craig B Thompson
Journal:  Proc Natl Acad Sci U S A       Date:  2008-11-24       Impact factor: 11.205

3.  Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis.

Authors:  Jason W Locasale; Alexandra R Grassian; Tamar Melman; Costas A Lyssiotis; Katherine R Mattaini; Adam J Bass; Gregory Heffron; Christian M Metallo; Taru Muranen; Hadar Sharfi; Atsuo T Sasaki; Dimitrios Anastasiou; Edouard Mullarky; Natalie I Vokes; Mika Sasaki; Rameen Beroukhim; Gregory Stephanopoulos; Azra H Ligon; Matthew Meyerson; Andrea L Richardson; Lynda Chin; Gerhard Wagner; John M Asara; Joan S Brugge; Lewis C Cantley; Matthew G Vander Heiden
Journal:  Nat Genet       Date:  2011-07-31       Impact factor: 38.330

4.  Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism.

Authors:  Haoqiang Ying; Alec C Kimmelman; Costas A Lyssiotis; Sujun Hua; Gerald C Chu; Eliot Fletcher-Sananikone; Jason W Locasale; Jaekyoung Son; Hailei Zhang; Jonathan L Coloff; Haiyan Yan; Wei Wang; Shujuan Chen; Andrea Viale; Hongwu Zheng; Ji-hye Paik; Carol Lim; Alexander R Guimaraes; Eric S Martin; Jeffery Chang; Aram F Hezel; Samuel R Perry; Jian Hu; Boyi Gan; Yonghong Xiao; John M Asara; Ralph Weissleder; Y Alan Wang; Lynda Chin; Lewis C Cantley; Ronald A DePinho
Journal:  Cell       Date:  2012-04-27       Impact factor: 41.582

5.  Glycine decarboxylase activity drives non-small cell lung cancer tumor-initiating cells and tumorigenesis.

Authors:  Wen Cai Zhang; Ng Shyh-Chang; He Yang; Amit Rai; Shivshankar Umashankar; Siming Ma; Boon Seng Soh; Li Li Sun; Bee Choo Tai; Min En Nga; Kishore Kumar Bhakoo; Senthil Raja Jayapal; Massimo Nichane; Qiang Yu; Dokeu A Ahmed; Christie Tan; Wong Poo Sing; John Tam; Agasthian Thirugananam; Monireh Soroush Noghabi; Yin Huei Pang; Haw Siang Ang; Wayne Mitchell; Paul Robson; Philipp Kaldis; Ross Andrew Soo; Sanjay Swarup; Elaine Hsuen Lim; Bing Lim
Journal:  Cell       Date:  2012-01-05       Impact factor: 41.582

6.  The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism.

Authors:  Carlos Sebastián; Bernadette M M Zwaans; Dafne M Silberman; Melissa Gymrek; Alon Goren; Lei Zhong; Oren Ram; Jessica Truelove; Alexander R Guimaraes; Debra Toiber; Claudia Cosentino; Joel K Greenson; Alasdair I MacDonald; Liane McGlynn; Fraser Maxwell; Joanne Edwards; Sofia Giacosa; Ernesto Guccione; Ralph Weissleder; Bradley E Bernstein; Aviv Regev; Paul G Shiels; David B Lombard; Raul Mostoslavsky
Journal:  Cell       Date:  2012-12-07       Impact factor: 41.582

Review 7.  Understanding the Warburg effect: the metabolic requirements of cell proliferation.

Authors:  Matthew G Vander Heiden; Lewis C Cantley; Craig B Thompson
Journal:  Science       Date:  2009-05-22       Impact factor: 47.728

8.  The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha.

Authors:  Lei Zhong; Agustina D'Urso; Debra Toiber; Carlos Sebastian; Ryan E Henry; Douangsone D Vadysirisack; Alexander Guimaraes; Brett Marinelli; Jakob D Wikstrom; Tomer Nir; Clary B Clish; Bhavapriya Vaitheesvaran; Othon Iliopoulos; Irwin Kurland; Yuval Dor; Ralph Weissleder; Orian S Shirihai; Leif W Ellisen; Joaquin M Espinosa; Raul Mostoslavsky
Journal:  Cell       Date:  2010-01-22       Impact factor: 41.582

9.  Functional genomics reveal that the serine synthesis pathway is essential in breast cancer.

Authors:  Richard Possemato; Kevin M Marks; Yoav D Shaul; Michael E Pacold; Dohoon Kim; Kıvanç Birsoy; Shalini Sethumadhavan; Hin-Koon Woo; Hyun G Jang; Abhishek K Jha; Walter W Chen; Francesca G Barrett; Nicolas Stransky; Zhi-Yang Tsun; Glenn S Cowley; Jordi Barretina; Nada Y Kalaany; Peggy P Hsu; Kathleen Ottina; Albert M Chan; Bingbing Yuan; Levi A Garraway; David E Root; Mari Mino-Kenudson; Elena F Brachtel; Edward M Driggers; David M Sabatini
Journal:  Nature       Date:  2011-08-18       Impact factor: 49.962

Review 10.  HIF and c-Myc: sibling rivals for control of cancer cell metabolism and proliferation.

Authors:  John D Gordan; Craig B Thompson; M Celeste Simon
Journal:  Cancer Cell       Date:  2007-08       Impact factor: 31.743
  10 in total
  15 in total

1.  A crucial role of SUMOylation in modulating Sirt6 deacetylation of H3 at lysine 56 and its tumor suppressive activity.

Authors:  J Cai; Y Zuo; T Wang; Y Cao; R Cai; F-L Chen; J Cheng; J Mu
Journal:  Oncogene       Date:  2016-02-22       Impact factor: 9.867

2.  ABHD5 interacts with BECN1 to regulate autophagy and tumorigenesis of colon cancer independent of PNPLA2.

Authors:  Yuan Peng; Hongming Miao; Shuang Wu; Weiwen Yang; Yue Zhang; Ganfeng Xie; Xiong Xie; Jianjun Li; Chunmeng Shi; Lilin Ye; Wei Sun; Liting Wang; Houjie Liang; Juanjuan Ou
Journal:  Autophagy       Date:  2016-08-25       Impact factor: 16.016

3.  Loss of abhd5 promotes colorectal tumor development and progression by inducing aerobic glycolysis and epithelial-mesenchymal transition.

Authors:  Juanjuan Ou; Hongming Miao; Yinyan Ma; Feng Guo; Jia Deng; Xing Wei; Jie Zhou; Ganfeng Xie; Hang Shi; Bingzhong Xue; Houjie Liang; Liqing Yu
Journal:  Cell Rep       Date:  2014-12-04       Impact factor: 9.423

4.  Epidermal growth factor receptor mediated proliferation depends on increased lipid droplet density regulated via a negative regulatory loop with FOXO3/Sirtuin6.

Authors:  Harrison Penrose; Sandra Heller; Chloe Cable; Rania Makboul; Gita Chadalawada; Ying Chen; Susan E Crawford; Suzana D Savkovic
Journal:  Biochem Biophys Res Commun       Date:  2015-11-30       Impact factor: 3.575

Review 5.  Modulation of p53 during bacterial infections.

Authors:  Christine Siegl; Thomas Rudel
Journal:  Nat Rev Microbiol       Date:  2015-11-09       Impact factor: 60.633

6.  Targeted inhibition of SIRT6 via engineered exosomes impairs tumorigenesis and metastasis in prostate cancer.

Authors:  Qing Han; Qian Rueben Xie; Fan Li; Yirui Cheng; Tingyu Wu; Yanshuang Zhang; Xin Lu; Alice S T Wong; Jianjun Sha; Weiliang Xia
Journal:  Theranostics       Date:  2021-04-26       Impact factor: 11.556

Review 7.  What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer.

Authors:  Julie-Aurore Losman; William G Kaelin
Journal:  Genes Dev       Date:  2013-04-15       Impact factor: 12.890

8.  Genotype directed therapy in murine mismatch repair deficient tumors.

Authors:  Melanie H Kucherlapati; Shadi Esfahani; Peiman Habibollahi; Junning Wang; Eric R Still; Roderick T Bronson; Umar Mahmood; Raju S Kucherlapati
Journal:  PLoS One       Date:  2013-07-23       Impact factor: 3.240

9.  Metabolic Effects of Known and Novel HDAC and SIRT Inhibitors in Glioblastomas Independently or Combined with Temozolomide.

Authors:  Miroslava Cuperlovic-Culf; Mohamed Touaibia; Patrick-Denis St-Coeur; Julie Poitras; Pier Morin; Adrian S Culf
Journal:  Metabolites       Date:  2014-09-12

10.  Cancer metabolism of cone photoreceptors.

Authors:  Thierry Léveillard
Journal:  Oncotarget       Date:  2015-10-20
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