| Literature DB >> 23217679 |
Abstract
HCN channels and their modulation by cAMP play a key role in cardiac pacemaking. In this issue of Structure, Xu and colleagues reveal that an arrhythmia-causing mutation of an HCN channel weakens cAMP binding to the channel by altering the local structure of its entry-exit pathway.Entities:
Year: 2012 PMID： 23217679 PMCID： PMC3521538 DOI： 10.1016/j.str.2012.11.007
Source DB: PubMed Journal: Structure ISSN： 0969-2126 Impact factor: 5.006