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Literature DB >> 23217578

A preliminary examination of how serotonergic polymorphisms influence brain response following an adolescent cannabis intervention.

Sarah W Feldstein Ewing¹, Hilary K Mead, Uma Yezhuvath, Sam Dewitt, Kent E Hutchison, Francesca M Filbey.

Abstract

Given the link between depression, anxiety, and cannabis abuse, a serotonin receptor (rs6311) and transporter polymorphism (rs2020936) were examined as moderators of neural response as measured by functional magnetic resonance imaging following a psychosocial treatment for cannabis use disorders (CUDs). While the proposed hypotheses were unsupported, we found that the rs6311 C allele was significantly related to brain activation (medial frontal gyrus, precuneus), indicating the role of this serotonin receptor in adolescent treatment response.

Entities: CellLine Chemical Disease Gene Mutation Species

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Year: 2012 PMID： 23217578 PMCID： PMC3544473 DOI： 10.1016/j.pscychresns.2012.10.011

Source DB: PubMed Journal: Psychiatry Res ISSN： 0165-1781 Impact factor: 3.222

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