BACKGROUND AND PURPOSE: Despite advances in the understanding of Huntington's disease (HD), treatment remains symptomatic. Multidisciplinary rehabilitation, however, appears to impact disease progression. Here we show the feasibility, safety and efficacy of a 9-month multidisciplinary rehabilitation programme in a small cohort of patients with early-to-middle-stage HD. METHODS:Twenty patients with HD were assigned to two groups, equally matched for cognitive and motor scores. One group received the intervention, whilst the other served as control. The Unified-Huntington's-Disease-Rating-Scale-Total-Motor-Score was the primary outcome measure. Neurocognitive/psychological tests, body composition, postural stability, strength and quality of life assessments were secondary outcome measures. RESULTS: The intervention reduced motor and postural stability deterioration, with minor improvements in depression, cognition and quality of life. Significant gains were observed for fat-free mass and strength. CONCLUSION: This pilot study suggests that a prolonged multidisciplinary rehabilitation programme in early-to-middle-stage HD is feasible, well-tolerated and associated with therapeutic benefit. Further explorative, larger studies are warranted.
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BACKGROUND AND PURPOSE: Despite advances in the understanding of Huntington's disease (HD), treatment remains symptomatic. Multidisciplinary rehabilitation, however, appears to impact disease progression. Here we show the feasibility, safety and efficacy of a 9-month multidisciplinary rehabilitation programme in a small cohort of patients with early-to-middle-stage HD. METHODS: Twenty patients with HD were assigned to two groups, equally matched for cognitive and motor scores. One group received the intervention, whilst the other served as control. The Unified-Huntington's-Disease-Rating-Scale-Total-Motor-Score was the primary outcome measure. Neurocognitive/psychological tests, body composition, postural stability, strength and quality of life assessments were secondary outcome measures. RESULTS: The intervention reduced motor and postural stability deterioration, with minor improvements in depression, cognition and quality of life. Significant gains were observed for fat-free mass and strength. CONCLUSION: This pilot study suggests that a prolonged multidisciplinary rehabilitation programme in early-to-middle-stage HD is feasible, well-tolerated and associated with therapeutic benefit. Further explorative, larger studies are warranted.
Authors: Travis M Cruickshank; Jennifer A Thompson; Juan F Domínguez D; Alvaro P Reyes; Mike Bynevelt; Nellie Georgiou-Karistianis; Roger A Barker; Mel R Ziman Journal: Brain Behav Date: 2015-01-15 Impact factor: 2.708
Authors: Marleen R van Walsem; Anu Piira; Geir Mikalsen; Hanne Ludt Fossmo; Emilie I Howe; SynnØve F Knutsen; Jan C Frich Journal: J Huntingtons Dis Date: 2018
Authors: Tiago A Mestre; Monica Busse; Aileen M Davis; Lori Quinn; Filipe B Rodrigues; Jean-Marc Burgunder; Noelle E Carlozzi; Francis Walker; Aileen K Ho; Cristina Sampaio; Christopher G Goetz; Esther Cubo; Pablo Martinez-Martin; Glenn T Stebbins Journal: Mov Disord Clin Pract Date: 2018-05-09
Authors: Monica Busse; Lori Quinn; Cheney Drew; Mark Kelson; Rob Trubey; Kirsten McEwan; Carys Jones; Julia Townson; Helen Dawes; Rhiannon Tudor-Edwards; Anne Rosser; Kerenza Hood Journal: Phys Ther Date: 2017-06-01
Authors: Nora E Fritz; Ashwini K Rao; Deb Kegelmeyer; Anne Kloos; Monica Busse; Lynda Hartel; Judith Carrier; Lori Quinn Journal: J Huntingtons Dis Date: 2017