| Literature DB >> 23214948 |
Morgane Petit1, Christine Tran, Thomas Roger, Thibault Gallavardin, Hamid Dhimane, Francisco Palma-Cerda, Mireille Blanchard-Desce, Francine C Acher, David Ogden, Peter I Dalko.
Abstract
The systematic SAR study of a "caging" group showed a strong influence of the position of the donor dimethylamino group on the efficiency of photolysis of the DMAQ (2-hydroxymethylene-(N,N-dimethylamino)quinoline) caged acetate under one-photon near-UV or two-photon near-IR excitation. Photorelease of l-glutamate by the most efficient 8-DMAQ derivative strongly and efficiently activated glutamate receptors, generating large, fast rising responses similar to those elicited by glutamate photoreleased from the widely used MNI-caged glutamate.Entities:
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Year: 2012 PMID： 23214948 DOI： 10.1021/ol3031704
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005