Literature DB >> 23212475

New insights into the regulation and cellular functions of the ARP2/3 complex.

Jeremy D Rotty1, Congying Wu, James E Bear.   

Abstract

The actin-related protein 2/3 (ARP2/3) complex nucleates branched actin filament networks, but requires nucleation promoting factors (NPFs) to stimulate this activity. NPFs include proteins such as Wiskott-Aldrich syndrome protein (WASP), neural WASP (NWASP), WASP family verprolin-homologous protein (WAVE; also known as SCAR) and the recently identified WASP and SCAR homologue (WASH) complex. The mechanisms underlying NPF-dependent regulation and the cellular functions of ARP2/3 are being unravelled using new chemical and genetic approaches. Of particular interest is the role of the ARP2/3 complex in vesicular trafficking and directional cell motility.

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Year:  2012        PMID： 23212475     DOI： 10.1038/nrm3492

Source DB:  PubMed          Journal:  Nat Rev Mol Cell Biol        ISSN： 1471-0072            Impact factor:   94.444


  45 in total

1.  A novel cofactor for p300 that regulates the p53 response.

Authors:  N Shikama; C W Lee; S France; L Delavaine; J Lyon; M Krstic-Demonacos; N B La Thangue
Journal:  Mol Cell       Date:  1999-09       Impact factor: 17.970

Review 2.  Regulation of actin polymerization by Arp2/3 complex and WASp/Scar proteins.

Authors:  H N Higgs; T D Pollard
Journal:  J Biol Chem       Date:  1999-11-12       Impact factor: 5.157

3.  GMF is a cofilin homolog that binds Arp2/3 complex to stimulate filament debranching and inhibit actin nucleation.

Authors:  Meghal Gandhi; Benjamin A Smith; Miia Bovellan; Ville Paavilainen; Karen Daugherty-Clarke; Jeff Gelles; Pekka Lappalainen; Bruce L Goode
Journal:  Curr Biol       Date:  2010-04-01       Impact factor: 10.834

4.  Cortactin promotes and stabilizes Arp2/3-induced actin filament network formation.

Authors:  A M Weaver; A V Karginov; A W Kinley; S A Weed; Y Li; J T Parsons; J A Cooper
Journal:  Curr Biol       Date:  2001-03-06       Impact factor: 10.834

5.  Actin polymerization is induced by Arp2/3 protein complex at the surface of Listeria monocytogenes.

Authors:  M D Welch; A Iwamatsu; T J Mitchison
Journal:  Nature       Date:  1997-01-16       Impact factor: 49.962

6.  N-WASP regulates the epithelial junctional actin cytoskeleton through a non-canonical post-nucleation pathway.

Authors:  Eva M Kovacs; Suzie Verma; Radiya G Ali; Aparna Ratheesh; Nicholas A Hamilton; Anna Akhmanova; Alpha S Yap
Journal:  Nat Cell Biol       Date:  2011-07-24       Impact factor: 28.824

7.  Interactions of isolated C-terminal fragments of neural Wiskott-Aldrich syndrome protein (N-WASP) with actin and Arp2/3 complex.

Authors:  Jean-François Gaucher; Chloé Maugé; Dominique Didry; Bérengère Guichard; Louis Renault; Marie-France Carlier
Journal:  J Biol Chem       Date:  2012-07-30       Impact factor: 5.157

8.  Coronin 1B antagonizes cortactin and remodels Arp2/3-containing actin branches in lamellipodia.

Authors:  Liang Cai; Alexander M Makhov; Dorothy A Schafer; James E Bear
Journal:  Cell       Date:  2008-09-05       Impact factor: 41.582

9.  Trafficking defects in WASH-knockout fibroblasts originate from collapsed endosomal and lysosomal networks.

Authors:  Timothy S Gomez; Jacquelyn A Gorman; Amaia Artal-Martinez de Narvajas; Alexander O Koenig; Daniel D Billadeau
Journal:  Mol Biol Cell       Date:  2012-06-20       Impact factor: 4.138

10.  Human subtelomeric WASH genes encode a new subclass of the WASP family.

Authors:  Elena V Linardopoulou; Sean S Parghi; Cynthia Friedman; Gregory E Osborn; Susan M Parkhurst; Barbara J Trask
Journal:  PLoS Genet       Date:  2007-12       Impact factor: 5.917
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  225 in total

1.  The Sharpin interactome reveals a role for Sharpin in lamellipodium formation via the Arp2/3 complex.

Authors:  Meraj H Khan; Siiri I Salomaa; Guillaume Jacquemet; Umar Butt; Mitro Miihkinen; Takahiro Deguchi; Elena Kremneva; Pekka Lappalainen; Martin J Humphries; Jeroen Pouwels
Journal:  J Cell Sci       Date:  2017-08-03       Impact factor: 5.285

2.  Competition and collaboration between different actin assembly pathways allows for homeostatic control of the actin cytoskeleton.

Authors:  Jeremy D Rotty; James E Bear
Journal:  Bioarchitecture       Date:  2015-10-02

3.  Crumbs is an essential regulator of cytoskeletal dynamics and cell-cell adhesion during dorsal closure in Drosophila.

Authors:  David Flores-Benitez; Elisabeth Knust
Journal:  Elife       Date:  2015-11-06       Impact factor: 8.140

4.  Comprehensive Proteomic and Metabolomic Signatures of Nontypeable Haemophilus influenzae-Induced Acute Otitis Media Reveal Bacterial Aerobic Respiration in an Immunosuppressed Environment.

Authors:  Alistair Harrison; Laura G Dubois; Lisa St John-Williams; M Arthur Moseley; Rachael L Hardison; Derek R Heimlich; Alexander Stoddard; Joseph E Kerschner; Sheryl S Justice; J Will Thompson; Kevin M Mason
Journal:  Mol Cell Proteomics       Date:  2015-12-28       Impact factor: 5.911

Review 5.  Plasticity of dendritic spines: subcompartmentalization of signaling.

Authors:  Lesley A Colgan; Ryohei Yasuda
Journal:  Annu Rev Physiol       Date:  2013-11-06       Impact factor: 19.318

Review 6.  Actin regulation by tropomodulin and tropomyosin in neuronal morphogenesis and function.

Authors:  Kevin T Gray; Alla S Kostyukova; Thomas Fath
Journal:  Mol Cell Neurosci       Date:  2017-04-19       Impact factor: 4.314

7.  RTN4 Knockdown Dysregulates the AKT Pathway, Destabilizes the Cytoskeleton, and Enhances Paclitaxel-Induced Cytotoxicity in Cancers.

Authors:  Gopal P Pathak; Rashmi Shah; Barry E Kennedy; J Patrick Murphy; Derek Clements; Prathyusha Konda; Michael Giacomantonio; Zhaolin Xu; Isabel R Schlaepfer; Shashi Gujar
Journal:  Mol Ther       Date:  2018-06-30       Impact factor: 11.454

8.  Actin-related protein2/3 complex regulates tight junctions and terminal differentiation to promote epidermal barrier formation.

Authors:  Kang Zhou; Andrew Muroyama; Julie Underwood; Rebecca Leylek; Samriddha Ray; Scott H Soderling; Terry Lechler
Journal:  Proc Natl Acad Sci U S A       Date:  2013-09-16       Impact factor: 11.205

9.  Wash exhibits context-dependent phenotypes and, along with the WASH regulatory complex, regulates Drosophila oogenesis.

Authors:  Jeffrey M Verboon; Jacob R Decker; Mitsutoshi Nakamura; Susan M Parkhurst
Journal:  J Cell Sci       Date:  2018-04-13       Impact factor: 5.285

10.  Mesenchymal chemotaxis requires selective inactivation of myosin II at the leading edge via a noncanonical PLCγ/PKCα pathway.

Authors:  Sreeja B Asokan; Heath E Johnson; Anisur Rahman; Samantha J King; Jeremy D Rotty; Irina P Lebedeva; Jason M Haugh; James E Bear
Journal:  Dev Cell       Date:  2014-12-04       Impact factor: 12.270
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