Literature DB >> 23210628

Convenient method for the synthesis of a flexible cyclic polyamide for selective targeting of c-myb G-quadruplex DNA.

Qiang Zhang1, Xiaojie Cui, Sen Lin, Jiang Zhou, Gu Yuan.   

Abstract

A convenient efficient method for synthesis of a flexible cyclic polyamide (cβ, 1) was developed through cyclodimerization. Electrospray ionization mass spectrometry and nuclear magnetic resonance results showed that 1 selectively binds to the c-myb G-quadruplex with high affinity, and there was no binding with the ILPR, bcl-2, and c-kit G-quadruplexes. This is the first time that a flexible cyclic polyamide was found to have high selectivity for the c-myb G-quadruplex.

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Year:  2012        PMID： 23210628     DOI： 10.1021/ol302918f

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  3 in total

1.  ESI mass spectrometric exploration of selective recognition of G-quadruplex in c-myb oncogene promoter using a novel flexible cyclic polyamide.

Authors:  Xiaojie Cui; Qiang Zhang; Han Chen; Jiang Zhou; Gu Yuan
Journal:  J Am Soc Mass Spectrom       Date:  2014-01-23       Impact factor: 3.109

2.  Regulation of PDGFR-β gene expression by targeting the G-vacancy bearing G-quadruplex in promoter.

Authors:  Juan-Nan Chen; Yi-de He; Hui-Ting Liang; Ting-Ting Cai; Qi Chen; Ke-Wei Zheng
Journal:  Nucleic Acids Res       Date:  2021-12-16       Impact factor: 16.971

3.  Exploration of the Structure and Recognition of a G-quadruplex in the her2 Proto-oncogene Promoter and Its Transcriptional Regulation.

Authors:  Xiaojie Cui; Han Chen; Qiang Zhang; Ming Xu; Gu Yuan; Jiang Zhou
Journal:  Sci Rep       Date:  2019-03-08       Impact factor: 4.379
  3 in total

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