Literature DB >> 2321017

A cellular automation model of excitable media including curvature and dispersion.

M Gerhardt1, H Schuster, J J Tyson.   

Abstract

Excitable media are spatially distributed systems characterized by their ability to propagate signals undamped over long distances. Wave propagation in excitable media has been modeled extensively both by continuous partial differential equations and by discrete cellular automata. Cellular automata are desirable because of their intuitive appeal and efficient digital implementation, but until now they have not served as reliable models because they have lacked two essential properties of excitable media. First, traveling waves show dispersion, that is, the speed of wave propagation into a recovering region depends on the time elapsed since the preceding wave passed through that region. Second, wave speed depends on wave front curvature: curved waves travel with normal velocities noticeably different from the plane-wave velocity. These deficiencies of cellular automation models are remedied by revising the classical rules of the excitation and recovery processes. The revised model shows curvature and dispersion effects comparable to those of continuous models, it predicts rotating spiral wave solutions in quantitative accord with the theory of continuous excitable media, and it is parameterized so that the spatial step size of the automation can be adjusted for finer resolution of traveling waves.

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Year:  1990        PMID: 2321017     DOI: 10.1126/science.2321017

Source DB:  PubMed          Journal:  Science        ISSN: 0036-8075            Impact factor:   47.728


  16 in total

1.  Formation of planar and spiral Ca2+ waves in isolated cardiac myocytes.

Authors:  H Ishida; C Genka; Y Hirota; H Nakazawa; W H Barry
Journal:  Biophys J       Date:  1999-10       Impact factor: 4.033

2.  An automaton model for the cell cycle.

Authors:  Atilla Altinok; Didier Gonze; Francis Lévi; Albert Goldbeter
Journal:  Interface Focus       Date:  2010-11-24       Impact factor: 3.906

3.  Bursting calcium rotors in cultured cardiac myocyte monolayers.

Authors:  G Bub; L Glass; N G Publicover; A Shrier
Journal:  Proc Natl Acad Sci U S A       Date:  1998-08-18       Impact factor: 11.205

Review 4.  Mathematical Models of Electrical Activity in Plants.

Authors:  Ekaterina Sukhova; Elena Akinchits; Vladimir Sukhov
Journal:  J Membr Biol       Date:  2017-07-15       Impact factor: 1.843

5.  Towards fungal computer.

Authors:  Andrew Adamatzky
Journal:  Interface Focus       Date:  2018-10-19       Impact factor: 3.906

Review 6.  Multi-scale modeling in biology: how to bridge the gaps between scales?

Authors:  Zhilin Qu; Alan Garfinkel; James N Weiss; Melissa Nivala
Journal:  Prog Biophys Mol Biol       Date:  2011-06-23       Impact factor: 3.667

7.  The relation between atrial fibrillation wavefront characteristics and accessory pathway conduction.

Authors:  J J Ong; Y M Cha; J M Kriett; K Boyce; G K Feld; P S Chen
Journal:  J Clin Invest       Date:  1995-11       Impact factor: 14.808

8.  Two-dimensional model of calcium waves reproduces the patterns observed in Xenopus oocytes.

Authors:  S Girard; A Lückhoff; J Lechleiter; J Sneyd; D Clapham
Journal:  Biophys J       Date:  1992-02       Impact factor: 4.033

9.  Heterogeneous incidence and propagation of spreading depolarizations.

Authors:  Dan Kaufmann; Jeremy J Theriot; Jekaterina Zyuzin; C Austin Service; Joshua C Chang; Y Tanye Tang; Vladimir B Bogdanov; Sylvie Multon; Jean Schoenen; Y Sungtaek Ju; K C Brennan
Journal:  J Cereb Blood Flow Metab       Date:  2016-01-01       Impact factor: 6.200

10.  Microscopic spiral waves reveal positive feedback in subcellular calcium signaling.

Authors:  P Lipp; E Niggli
Journal:  Biophys J       Date:  1993-12       Impact factor: 4.033

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