AIM: To observe the outcomes of 1H- MR-spectroscopy (MRS) guided gamma knife surgery for treatment of glioma. MATERIAL AND METHODS:Twenty patients with glioma diagnosed pathologically were randomly divided into MRI group and MRI plus MRS group. The target volume was defined as the tumor enhanced area plus the surrounding area with a short T1 and a long T2 in the MRI group, while the tumor enhanced area plus the surrounding area with a short T1 and a long T2 and choline: N-acetyl aspartate index (CNI) ≥ 1.6 in the MRI plus MRS group.12 months after surgery were set as the endpoint. RESULTS:Thirteen (65%) patients were successfully treated, of whom 6 were in the MRI group and 7 in the MRI plus MRS group. Ten patients suffered from cerebral edema during treatment, including 8 in the MRI group and 2 in the other group. The cases of cerebral edema were significantly fewer in the MRI plus MRS group than the MRI group. The average maximum diameter of the target volume was smaller in the MRI plus MRS group. CONCLUSION: The MRS-guided gamma knife radiosurgery helps to identify and remove the lesion of glioma and reduce complications due to extended surgical scope.
RCT Entities:
AIM: To observe the outcomes of 1H- MR-spectroscopy (MRS) guided gamma knife surgery for treatment of glioma. MATERIAL AND METHODS: Twenty patients with glioma diagnosed pathologically were randomly divided into MRI group and MRI plus MRS group. The target volume was defined as the tumor enhanced area plus the surrounding area with a short T1 and a long T2 in the MRI group, while the tumor enhanced area plus the surrounding area with a short T1 and a long T2 and choline: N-acetyl aspartate index (CNI) ≥ 1.6 in the MRI plus MRS group.12 months after surgery were set as the endpoint. RESULTS: Thirteen (65%) patients were successfully treated, of whom 6 were in the MRI group and 7 in the MRI plus MRS group. Ten patients suffered from cerebral edema during treatment, including 8 in the MRI group and 2 in the other group. The cases of cerebral edema were significantly fewer in the MRI plus MRS group than the MRI group. The average maximum diameter of the target volume was smaller in the MRI plus MRS group. CONCLUSION: The MRS-guided gamma knife radiosurgery helps to identify and remove the lesion of glioma and reduce complications due to extended surgical scope.