BACKGROUND: : Histologic specimens obtained by endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) often provide valuable information for diagnosis or management decisions; however, little has been reported about the sampling yield. Besides the conventional 22-gauge needle, a 21-gauge needle is now available for this procedure. The purpose of this study was to elucidate and compare the respective histologic specimen retrieval yields of EBUS-TBNA using 21-gauge and 22-gauge needles. METHODS: : Sixty patients with hilar/mediastinal lymphadenopathy or a tumor adjacent to the central airway were enrolled and randomized to undergo EBUS-TBNA using a 21-gauge or a 22-gauge needle. Each histologic specimen obtained by EBUS-TBNA on the initial 2 punctures of each patient (total 120 punctures) was blindly categorized by a pathologist as follows: I, diagnostic; II, nondiagnostic but adequate (eg, lymphoid tissue); III, nondiagnostic and inadequate (eg, clot); and IV, no specimens. RESULTS: : The specimens obtained by the 21-gauge needle were interpreted as I in 35, II in 8, III in 15, and IV in 2. The specimens obtained by the 22-gauge needle were judged to be I in 34, II in 13, III in 7, and IV in 6. The sampling yield of adequate histologic specimens (I and II) obtained by the 21-gauge and 22-gauge needles was 72% and 78% (P=0.40), respectively. No complications were associated with the procedures. CONCLUSIONS: : Histologic specimens can be obtained with a high sampling yield using either of the needles. Our study found no difference in the sampling yield between the 2 needles.
RCT Entities:
BACKGROUND: : Histologic specimens obtained by endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) often provide valuable information for diagnosis or management decisions; however, little has been reported about the sampling yield. Besides the conventional 22-gauge needle, a 21-gauge needle is now available for this procedure. The purpose of this study was to elucidate and compare the respective histologic specimen retrieval yields of EBUS-TBNA using 21-gauge and 22-gauge needles. METHODS: : Sixty patients with hilar/mediastinal lymphadenopathy or a tumor adjacent to the central airway were enrolled and randomized to undergo EBUS-TBNA using a 21-gauge or a 22-gauge needle. Each histologic specimen obtained by EBUS-TBNA on the initial 2 punctures of each patient (total 120 punctures) was blindly categorized by a pathologist as follows: I, diagnostic; II, nondiagnostic but adequate (eg, lymphoid tissue); III, nondiagnostic and inadequate (eg, clot); and IV, no specimens. RESULTS: : The specimens obtained by the 21-gauge needle were interpreted as I in 35, II in 8, III in 15, and IV in 2. The specimens obtained by the 22-gauge needle were judged to be I in 34, II in 13, III in 7, and IV in 6. The sampling yield of adequate histologic specimens (I and II) obtained by the 21-gauge and 22-gauge needles was 72% and 78% (P=0.40), respectively. No complications were associated with the procedures. CONCLUSIONS: : Histologic specimens can be obtained with a high sampling yield using either of the needles. Our study found no difference in the sampling yield between the 2 needles.
Authors: Eric L Scholten; Roy Semaan; Peter Illei; Christopher Mallow; Sixto Arias; David Feller-Kopman; Karen Oakjones-Burgess; Bernice Frimpong; Ricardo Ortiz; Hans Lee; Lonny Yarmus Journal: Chest Date: 2016-10-18 Impact factor: 9.410
Authors: Nicola Rotolo; Andrea Imperatori; Mario Nosotti; Luigi Santambrogio; Alessandro Palleschi; Lorenzo Dominioni; Giorgio Crosta; Pierfranco Foccoli; Gianluca Pariscenti; Eliseo Passera; Luigi Bortolotti; Giovanni Falezza; Maurizio Infante; Elisa Daffrè; Maria Cattoni; Lorenzo Rosso Journal: J Thorac Dis Date: 2017-05 Impact factor: 2.895
Authors: Lonny B Yarmus; Jason Akulian; Noah Lechtzin; Faiza Yasin; Biren Kamdar; Armin Ernst; David E Ost; Cynthia Ray; Sarah R Greenhill; Carlos A Jimenez; Joshua Filner; David Feller-Kopman Journal: Chest Date: 2013-04 Impact factor: 9.410
Authors: Nikhil Jagan; Carolina A Landeen; Douglas R Moore; Adam D Highley; Ryan W Walters; Zachary S DePew Journal: J Thorac Dis Date: 2019-08 Impact factor: 2.895
Authors: Adam H Fox; James R Jett; Upal Basu Roy; Bruce E Johnson; Jennifer C King; Nikki Martin; Raymond U Osarogiagbon; M Patricia Rivera; Lauren S Rosenthal; Robert A Smith; Gerard A Silvestri Journal: Chest Date: 2021-06-26 Impact factor: 9.410