BACKGROUND/AIMS: Knowledge about neuropsychiatric symptoms in young-onset Alzheimer's disease (YO-AD) is scarce, but essential to establish a prognosis and plan care for YO-AD patients. The aim of this study is to assess frequency parameters of neuropsychiatric symptoms in YO-AD over 2 years and investigate whether there are differences compared with late-onset Alzheimer's disease (LO-AD). METHODS: 98 YO-AD and 123 LO-AD patients and caregivers from two prospective cohort studies were included and assessed every 6 months for 2 years, using the Neuropsychiatric Inventory to evaluate neuropsychiatric symptoms. RESULTS: Over the course of 2 years, the incidence, prevalence and persistence of neuropsychiatric symptoms were in general lower in YO-AD than in LO-AD, specifically for delusions, agitation, depression, anxiety, apathy, irritability and aberrant motor behavior. Frequency of individual symptoms showed large variability in both groups. Within the group of YO-AD patients, apathy was the most prevalent symptom. CONCLUSION: Neuropsychiatric symptoms, notably apathy, should be paid appropriate attention to in the diagnosis and treatment of YO-AD patients. Further research is needed to gain insight into the mechanisms underlying the differences in neuropsychiatric symptoms between YO-AD and LO-AD.
BACKGROUND/AIMS: Knowledge about neuropsychiatric symptoms in young-onset Alzheimer's disease (YO-AD) is scarce, but essential to establish a prognosis and plan care for YO-ADpatients. The aim of this study is to assess frequency parameters of neuropsychiatric symptoms in YO-AD over 2 years and investigate whether there are differences compared with late-onset Alzheimer's disease (LO-AD). METHODS: 98 YO-AD and 123 LO-AD patients and caregivers from two prospective cohort studies were included and assessed every 6 months for 2 years, using the Neuropsychiatric Inventory to evaluate neuropsychiatric symptoms. RESULTS: Over the course of 2 years, the incidence, prevalence and persistence of neuropsychiatric symptoms were in general lower in YO-AD than in LO-AD, specifically for delusions, agitation, depression, anxiety, apathy, irritability and aberrant motor behavior. Frequency of individual symptoms showed large variability in both groups. Within the group of YO-ADpatients, apathy was the most prevalent symptom. CONCLUSION: Neuropsychiatric symptoms, notably apathy, should be paid appropriate attention to in the diagnosis and treatment of YO-ADpatients. Further research is needed to gain insight into the mechanisms underlying the differences in neuropsychiatric symptoms between YO-AD and LO-AD.
Authors: Tommaso Ballarini; Leonardo Iaccarino; Giuseppe Magnani; Nagehan Ayakta; Bruce L Miller; William J Jagust; Maria Luisa Gorno-Tempini; Gil D Rabinovici; Daniela Perani Journal: Hum Brain Mapp Date: 2016-07-13 Impact factor: 5.038
Authors: Neus Falgàs; Isabel E Allen; Salvatore Spina; Harli Grant; Stefanie D Piña Escudero; Jennifer Merrilees; Rosalie Gearhart; Howard J Rosen; Joel H Kramer; William W Seeley; Thomas C Neylan; Bruce L Miller; Gil D Rabinovici; Lea T Grinberg; Christine M Walsh Journal: Eur J Neurol Date: 2021-12-20 Impact factor: 6.288
Authors: Josephine Barnes; Bradford C Dickerson; Chris Frost; Lize C Jiskoot; David Wolk; Wiesje M van der Flier Journal: Alzheimers Dement Date: 2015-04-24 Impact factor: 21.566
Authors: Aud Johannessen; Knut Engedal; Per Kristian Haugen; Marcia Cristina Nascimento Dourado; Kirsten Thorsen Journal: Int J Qual Stud Health Well-being Date: 2018-12
Authors: Ans J M J Mulders; Sytse U Zuidema; Renée Leeuwis; Hans Bor; Frans R J Verhey; Raymond T C M Koopmans Journal: Int J Geriatr Psychiatry Date: 2019-04-29 Impact factor: 3.485