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Literature DB >> 23208207

Human ferredoxin-2 displays a unique conformational change.

Abstract

Human ferredoxin-1 (hFd1) and human ferredoxin-2 (hFd2) share high sequence similarity but serve on distinct cellular pathways. A unique conformational change is observed when holo hFd2 is warmed to physiological temperatures, or higher. Enzymatic studies show that this conformational change causes the increase of affinity between hFd2 and adrenodoxin reductase. No such change was observed for hFd1, which may contribute to the distinct cellular functions of hFd1 and hFd2 under physiological conditions.

Entities: Chemical Disease Gene Species

Mesh：

Substances：
Ferredoxins

Year: 2012 PMID： 23208207 PMCID： PMC3622203 DOI： 10.1039/c2dt32018e

Source DB: PubMed Journal: Dalton Trans ISSN： 1477-9226 Impact factor: 4.390

17 in total

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2. A mitochondrial ferredoxin is essential for biogenesis of cellular iron-sulfur proteins.

Authors: H Lange; A Kaut; G Kispal; R Lill
Journal: Proc Natl Acad Sci U S A Date: 2000-02-01 Impact factor: 11.205

3. Molecular recognition and electron transfer in mitochondrial steroid hydroxylase systems.

Authors: L E Vickery
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4. Effect of heat-induced structural perturbation of secondary and tertiary structures on the chaperone activity of alpha-crystallin.

Authors: J S Lee; T Satoh; H Shinoda; T Samejima; S H Wu; S H Chiou
Journal: Biochem Biophys Res Commun Date: 1997-08-18 Impact factor: 3.575

5. Humans possess two mitochondrial ferredoxins, Fdx1 and Fdx2, with distinct roles in steroidogenesis, heme, and Fe/S cluster biosynthesis.

Authors: Alex D Sheftel; Oliver Stehling; Antonio J Pierik; Hans-Peter Elsässer; Ulrich Mühlenhoff; Holger Webert; Anna Hobler; Frank Hannemann; Rita Bernhardt; Roland Lill
Journal: Proc Natl Acad Sci U S A Date: 2010-06-14 Impact factor: 11.205

6. Mitochondrial ferredoxin is required for heme A synthesis in Saccharomyces cerevisiae.

Authors: Mario H Barros; Francisco G Nobrega; Alexander Tzagoloff
Journal: J Biol Chem Date: 2002-01-11 Impact factor: 5.157

7. Adrenodoxin reductase homolog (Arh1p) of yeast mitochondria required for iron homeostasis.

Authors: J Li; S Saxena; D Pain; A Dancis
Journal: J Biol Chem Date: 2001-01-12 Impact factor: 5.157

8. Components involved in assembly and dislocation of iron-sulfur clusters on the scaffold protein Isu1p.

Authors: Ulrich Mühlenhoff; Jana Gerber; Nadine Richhardt; Roland Lill
Journal: EMBO J Date: 2003-09-15 Impact factor: 11.598

9. Iron-sulfur cluster biosynthesis. Kinetic analysis of [2Fe-2S] cluster transfer from holo ISU to apo Fd: role of redox chemistry and a conserved aspartate.

Authors: Shu-Pao Wu; Gong Wu; Kristene K Surerus; J A Cowan
Journal: Biochemistry Date: 2002-07-16 Impact factor: 3.162

10. Kinetics of heat inactivation of phenyl valerate hydrolases from hen and rat brain.

Authors: E Reiner; C S Davis; B W Schwab; L M Schopfer; R J Richardson
Journal: Biochem Pharmacol Date: 1987-10-01 Impact factor: 5.858

12 in total

1. Reconstitution, characterization, and [2Fe-2S] cluster exchange reactivity of a holo human BOLA3 homodimer.

Authors: Christine Wachnowsky; Brian Rao; Sambuddha Sen; Brian Fries; Cecil J Howard; Jennifer J Ottesen; J A Cowan
Journal: J Biol Inorg Chem Date: 2019-09-05 Impact factor: 3.358

2. Cluster exchange reactivity of [2Fe-2S] cluster-bridged complexes of BOLA3 with monothiol glutaredoxins.

Authors: Sambuddha Sen; Brian Rao; Christine Wachnowsky; J A Cowan
Journal: Metallomics Date: 2018-09-19 Impact factor: 4.526

3. Mapping cellular Fe-S cluster uptake and exchange reactions - divergent pathways for iron-sulfur cluster delivery to human ferredoxins.

Authors: Insiya Fidai; Christine Wachnowsky; J A Cowan
Journal: Metallomics Date: 2016-12-07 Impact factor: 4.526

4. Understanding the molecular basis for multiple mitochondrial dysfunctions syndrome 1 (MMDS1): impact of a disease-causing Gly189Arg substitution on NFU1.

Authors: Nathaniel A Wesley; Christine Wachnowsky; Insiya Fidai; J A Cowan
Journal: FEBS J Date: 2017-10-12 Impact factor: 5.542

5. Role of the HSPA9/HSC20 chaperone pair in promoting directional human iron-sulfur cluster exchange involving monothiol glutaredoxin 5.

Authors: Joshua A Olive; J A Cowan
Journal: J Inorg Biochem Date: 2018-04-11 Impact factor: 4.155

6. Iron-sulfur cluster exchange reactions mediated by the human Nfu protein.

Authors: Christine Wachnowsky; Insiya Fidai; J A Cowan
Journal: J Biol Inorg Chem Date: 2016-08-18 Impact factor: 3.358

7. Glutathione-complexed [2Fe-2S] clusters function in Fe-S cluster storage and trafficking.

Authors: Insiya Fidai; Christine Wachnowsky; J A Cowan
Journal: J Biol Inorg Chem Date: 2016-09-02 Impact factor: 3.358

8. Understanding the Molecular Basis of Multiple Mitochondrial Dysfunctions Syndrome 1 (MMDS1)-Impact of a Disease-Causing Gly208Cys Substitution on Structure and Activity of NFU1 in the Fe/S Cluster Biosynthetic Pathway.

Authors: Christine Wachnowsky; Nathaniel A Wesley; Insiya Fidai; J A Cowan
Journal: J Mol Biol Date: 2017-02-01 Impact factor: 5.469

9. Regulation of human Nfu activity in Fe-S cluster delivery-characterization of the interaction between Nfu and the HSPA9/Hsc20 chaperone complex.

Authors: Christine Wachnowsky; Yushi Liu; Taejin Yoon; J A Cowan
Journal: FEBS J Date: 2017-12-29 Impact factor: 5.542

10. Spectroscopic and functional characterization of the [2Fe-2S] scaffold protein Nfu from Synechocystis PCC6803.

Authors: Zechariah Thompson; Insiya Fidai; Christine Wachnowsky; Amber L Hendricks; J A Cowan
Journal: Biochimie Date: 2021-09-25 Impact factor: 4.079