| Literature DB >> 23208186 |
Yrjö T Konttinen1, Jukka Pajarinen.
Abstract
New data demonstrate that cobalt ions promote immune system activation through Toll-like receptor 4 signalling. This finding adds to our understanding of the adverse innate and adaptive immune reactions evoked by debris released from metal-on-metal total or resurfacing joint replacement implants, which have provoked recommendations against their use.Entities:
Mesh:
Substances:
Year: 2012 PMID: 23208186 DOI: 10.1038/nrrheum.2012.218
Source DB: PubMed Journal: Nat Rev Rheumatol ISSN: 1759-4790 Impact factor: 20.543