Literature DB >> 23206702

The APC/C activator Cdh1 regulates the G2/M transition during differentiation of placental trophoblast stem cells.

Hideaki Naoe1, Tatsuyuki Chiyoda, Jo Ishizawa, Kenta Masuda, Hideyuki Saya, Shinji Kuninaka.   

Abstract

Differentiation of placental trophoblast stem (TS) cells to trophoblast giant (TG) cells is accompanied by transition from a mitotic cell cycle to an endocycle. Here, we report that Cdh1, a regulator of the anaphase-promoting complex/cyclosome (APC/C), negatively regulates mitotic entry upon the mitotic/endocycle transition. TS cells derived from homozygous Cdh1 gene-trapped (Cdh1(GT/GT)) murine embryos accumulated mitotic cyclins and precociously entered mitosis after induction of TS cell differentiation, indicating that Cdh1 is required for the switch from mitosis to the endocycle. Furthermore, the Cdh1(GT/GT) TS cells and placenta showed aberrant expression of placental differentiation markers. These data highlight an important role of Cdh1 in the G2/M transition during placental differentiation.
Copyright © 2012 Elsevier Inc. All rights reserved.

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Year:  2012        PMID： 23206702     DOI： 10.1016/j.bbrc.2012.11.075

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  5 in total

1.  FZR1 loss increases sensitivity to DNA damage and consequently promotes murine and human B-cell acute leukemia.

Authors:  Jo Ishizawa; Eiji Sugihara; Shinji Kuninaka; Kaoru Mogushi; Kensuke Kojima; Christopher B Benton; Ran Zhao; Dhruv Chachad; Norisato Hashimoto; Rodrigo O Jacamo; Yihua Qiu; Suk Young Yoo; Shinichiro Okamoto; Michael Andreeff; Steven M Kornblau; Hideyuki Saya
Journal:  Blood       Date:  2017-01-31       Impact factor: 22.113

2.  Insufficiency of FZR1 disturbs HSC quiescence by inhibiting ubiquitin-dependent degradation of RUNX1 in aplastic anemia.

Authors:  Chengfang Zhou; Mei Kuang; Zhilong Liu; Xiaoqin Jia; Zhe Chen; Yuanyuan Liu; Zhigang Li; Weiru Wu; Le Ma; Jieping Chen; Yu Hou
Journal:  Leukemia       Date:  2021-10-11       Impact factor: 11.528

Review 3.  APC/C and retinoblastoma interaction: cross-talk of retinoblastoma protein with the ubiquitin proteasome pathway.

Authors:  Ajeena Ramanujan; Swati Tiwari
Journal:  Biosci Rep       Date:  2016-09-16       Impact factor: 3.840

4.  Chaperonin TRiC/CCT supports mitotic exit and entry into endocycle in Drosophila.

Authors:  Yuya Ohhara; Aki Nakamura; Yuki Kato; Kimiko Yamakawa-Kobayashi
Journal:  PLoS Genet       Date:  2019-04-29       Impact factor: 5.917

5.  Nucleotide variants of the cancer predisposing gene CDH1 and the risk of non-syndromic cleft lip with or without cleft palate.

Authors:  Kamil K Hozyasz; Adrianna Mostowska; Piotr Wójcicki; Agnieszka Lasota; Barbara Offert; Adam Balcerek; Izabella Dunin-Wilczyńska; Paweł P Jagodziński
Journal:  Fam Cancer       Date:  2014-09       Impact factor: 2.375
  5 in total

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