Z Li1, C Ma, L Li, X Pan, L Chen. 1. Department of Endocrinology, Fourth People's Hospital of Jinan City, Jinan, China.
Abstract
OBJECTIVE: To examine whether there is an association between the serum concentration of vaspin and the presence of carotid plaque in early stage type 2 diabetes mellitus (T2DM). METHODS: Patients (n = 61) with T2DM within 3 years of diagnosis were divided into those with and those without carotid plaque. Fasting serum vaspin levels, measured by enzymelinked immunosorbent assay, and blood pressure were compared between these two groups and also with an age-matched, apparently healthy control group (n = 26). RESULTS: Fasting serum vaspin concentrations were significantly higher in patients with T2DM without carotid plaque than in controls, but significantly lower in T2DM patients with carotid plaque than in those without. Multivariate logistic regression analysis showed a significant positive association between the presence of carotid plaque and systolic blood pressure and a significant inverse association between the presence of carotid plaque and fasting serum vaspin concentration. CONCLUSION: A significant inverse association was found, in patients with T2DM within 3 years of diagnosis, between serum vaspin concentration and the presence of carotid plaque.
OBJECTIVE: To examine whether there is an association between the serum concentration of vaspin and the presence of carotid plaque in early stage type 2 diabetes mellitus (T2DM). METHODS:Patients (n = 61) with T2DM within 3 years of diagnosis were divided into those with and those without carotid plaque. Fasting serum vaspin levels, measured by enzymelinked immunosorbent assay, and blood pressure were compared between these two groups and also with an age-matched, apparently healthy control group (n = 26). RESULTS: Fasting serum vaspin concentrations were significantly higher in patients with T2DM without carotid plaque than in controls, but significantly lower in T2DM patients with carotid plaque than in those without. Multivariate logistic regression analysis showed a significant positive association between the presence of carotid plaque and systolic blood pressure and a significant inverse association between the presence of carotid plaque and fasting serum vaspin concentration. CONCLUSION: A significant inverse association was found, in patients with T2DM within 3 years of diagnosis, between serum vaspin concentration and the presence of carotid plaque.
Authors: Javier Rueda-Gotor; Raquel López-Mejías; Sara Remuzgo-Martínez; Miguel Á González-Gay; Fernanda Genre; Verónica Pulito-Cueto; Alfonso Corrales; Leticia Lera-Gómez; Virginia Portilla; Íñigo González-Mazón; Ricardo Blanco; Rosa Expósito; Cristina Mata; Javier Llorca; Vanesa Hernández-Hernández; Carlos Rodríguez-Lozano; Nuria Barbarroja; Rafaela Ortega Castro; Esther Vicente; Cristina Fernández-Carballido; María Paz Martínez-Vidal; David Castro-Corredor; Joaquín Anino-Fernández; Diana Peiteado; Chamaida Plasencia-Rodríguez; Eva Galíndez-Agirregoikoa; María Luz García-Vivar; Oreste Gualillo; Juan Carlos Quevedo-Abeledo; Santos Castañeda; Iván Ferraz-Amaro Journal: Arthritis Res Ther Date: 2021-04-13 Impact factor: 5.156