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Literature DB >> 23205273

The efficiency of DPPH as a polarising agent for DNP-NMR spectroscopy.

Lloyd Lumata¹, Matthew Merritt, Chalermchai Khemtong, S James Ratnakar, Johan van Tol, Lu Yu, Likai Song, Zoltan Kovacs.

Abstract

The free radical 2,2-diphenyl-1-pycrylhydrazyl (DPPH) was tested as a polarising agent for fast dissolution dynamic nuclear polarisation (DNP) NMR spectroscopy. DPPH was found to be reasonably soluble in sulfolane and the optimum concentration for DNP is 20-40 mM depending upon whether short polarisation times or the maximum signal intensity is needed. W-band ESR measurements revealed that the ESR linewidth D of DPPH is intermediate between that of BDPA and 4-oxo-TEMPO. Several thousand-fold NMR signal enhancements in the liquid-state were achieved for (13)C, (15)N, (89)Y, and (109)Ag compounds, demonstrating that DPPH can be added to the list of polarising agents for DNP-NMR spectroscopy. Furthermore, the hydrophobic DPPH free radical can be easily filtered out from the dissolution liquid when water is used as the dissolution solvent.

Entities: Chemical Disease Gene

Year: 2012 PMID： 23205273 PMCID： PMC3507463 DOI： 10.1039/C2RA21853D

Source DB: PubMed Journal: RSC Adv ISSN： 2046-2069 Impact factor: 3.361

20 in total

1. Polychlorinated trityl radicals for dynamic nuclear polarization: the role of chlorine nuclei.

Authors: Juan Carlos Paniagua; Verónica Mugnaini; Cristina Gabellieri; Miguel Feliz; Nans Roques; Jaume Veciana; Miquel Pons
Journal: Phys Chem Chem Phys Date: 2010-05-10 Impact factor: 3.676

2. DPPH radical scavenging activity of tricin and its conjugates isolated from "Njavara" rice bran: a density functional theory study.

Authors: Manjaly J Ajitha; Smitha Mohanlal; Cherumuttathu H Suresh; Ananthasankaran Jayalekshmy
Journal: J Agric Food Chem Date: 2012-03-22 Impact factor: 5.279

3. DPPH as a Standard for High-Field EPR

Authors:
Journal: J Magn Reson Date: 1997-03 Impact factor: 2.229

4. Analysis of cancer metabolism by imaging hyperpolarized nuclei: prospects for translation to clinical research.

Authors: John Kurhanewicz; Daniel B Vigneron; Kevin Brindle; Eduard Y Chekmenev; Arnaud Comment; Charles H Cunningham; Ralph J Deberardinis; Gary G Green; Martin O Leach; Sunder S Rajan; Rahim R Rizi; Brian D Ross; Warren S Warren; Craig R Malloy
Journal: Neoplasia Date: 2011-02 Impact factor: 5.715

5. Longitudinal relaxation and diffusion measurements using magnetic resonance signals from laser-hyperpolarized 129Xe nuclei.

Authors: B R Patyal; J H Gao; R F Williams; J Roby; B Saam; B A Rockwell; R J Thomas; D J Stolarski; P T Fox
Journal: J Magn Reson Date: 1997-05 Impact factor: 2.229

6. BDPA: an efficient polarizing agent for fast dissolution dynamic nuclear polarization NMR spectroscopy.

Authors: Lloyd Lumata; S James Ratnakar; Ashish Jindal; Matthew Merritt; Arnaud Comment; Craig Malloy; A Dean Sherry; Zoltan Kovacs
Journal: Chemistry Date: 2011-08-25 Impact factor: 5.236

7. DNP by thermal mixing under optimized conditions yields >60,000-fold enhancement of 89Y NMR signal.

Authors: Lloyd Lumata; Ashish K Jindal; Matthew E Merritt; Craig R Malloy; A Dean Sherry; Zoltan Kovacs
Journal: J Am Chem Soc Date: 2011-05-13 Impact factor: 15.419

8. Production and NMR characterization of hyperpolarized (107,109)Ag complexes.

Authors: Lloyd Lumata; Matthew E Merritt; Zohreh Hashami; S James Ratnakar; Zoltan Kovacs
Journal: Angew Chem Int Ed Engl Date: 2011-10-13 Impact factor: 15.336

9. 1,1-diphenyl-2-picrylhydrazyl radical scavenging activity of bee products and their constituents determined by ESR.

Authors: Hiroshi Izuta; Yukimi Narahara; Masamitsu Shimazawa; Satoshi Mishima; Shin-ichi Kondo; Hideaki Hara
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10. Co-acquisition of hyperpolarised 13C and 15N NMR spectra.

Authors: Iain J Day; John C Mitchell; Martin J Snowden; Adrian L Davis
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13 in total

1. Enhanced Efficiency of ¹³C Dynamic Nuclear Polarization by Superparamagnetic Iron Oxide Nanoparticle Doping.

Authors: Peter Niedbalski; Christopher R Parish; Qing Wang; Zahra Hayati; Likai Song; Zackary I Cleveland; Lloyd Lumata
Journal: J Phys Chem C Nanomater Interfaces Date: 2017-08-17 Impact factor: 4.126

2. Effects of glassing matrix deuteration on the relaxation properties of hyperpolarized ¹³C spins and free radical electrons at cryogenic temperatures.

Authors: Christopher Parish; Peter Niedbalski; Qing Wang; Fatemeh Khashami; Zahra Hayati; Mengtian Liu; Likai Song; Lloyd Lumata
Journal: J Chem Phys Date: 2019-06-21 Impact factor: 3.488

3. Hybrid polarizing solids for pure hyperpolarized liquids through dissolution dynamic nuclear polarization.

Authors: David Gajan; Aurélien Bornet; Basile Vuichoud; Jonas Milani; Roberto Melzi; Henri A van Kalkeren; Laurent Veyre; Chloé Thieuleux; Matthew P Conley; Wolfram R Grüning; Martin Schwarzwälder; Anne Lesage; Christophe Copéret; Geoffrey Bodenhausen; Lyndon Emsley; Sami Jannin
Journal: Proc Natl Acad Sci U S A Date: 2014-09-29 Impact factor: 11.205

4. Influence of ¹³C Isotopic Labeling Location on Dynamic Nuclear Polarization of Acetate.

Authors: Peter Niedbalski; Christopher Parish; Andhika Kiswandhi; Zoltan Kovacs; Lloyd Lumata
Journal: J Phys Chem A Date: 2017-04-24 Impact factor: 2.781

5. Development and performance of a 129-GHz dynamic nuclear polarizer in an ultra-wide bore superconducting magnet.

Authors: Lloyd L Lumata; Richard Martin; Ashish K Jindal; Zoltan Kovacs; Mark S Conradi; Matthew E Merritt
Journal: MAGMA Date: 2014-08-14 Impact factor: 2.310

6. Influence of Dy³⁺ and Tb³⁺ doping on ¹³C dynamic nuclear polarization.

Authors: Peter Niedbalski; Christopher Parish; Andhika Kiswandhi; Leila Fidelino; Chalermchai Khemtong; Zahra Hayati; Likai Song; André Martins; A Dean Sherry; Lloyd Lumata
Journal: J Chem Phys Date: 2017-01-07 Impact factor: 3.488

7. Transition Metal Doping Reveals Link between Electron T₁ Reduction and ¹³C Dynamic Nuclear Polarization Efficiency.

Authors: Peter Niedbalski; Christopher Parish; Qing Wang; Zahra Hayati; Likai Song; André F Martins; A Dean Sherry; Lloyd Lumata
Journal: J Phys Chem A Date: 2017-11-21 Impact factor: 2.781

Review 8. Hyperpolarized (13)C Magnetic Resonance and Its Use in Metabolic Assessment of Cultured Cells and Perfused Organs.

Authors: Lloyd Lumata; Chendong Yang; Mukundan Ragavan; Nicholas Carpenter; Ralph J DeBerardinis; Matthew E Merritt
Journal: Methods Enzymol Date: 2015-06-14 Impact factor: 1.600

9. The influence of Ho³⁺ doping on ¹³C DNP in the presence of BDPA.

Authors: Ram B Khattri; Ali A Sirusi; Eul Hyun Suh; Zoltan Kovacs; Matthew E Merritt
Journal: Phys Chem Chem Phys Date: 2019-08-28 Impact factor: 3.676

Review 10. Chemistry and biochemistry of 13C hyperpolarized magnetic resonance using dynamic nuclear polarization.

Authors: Kayvan R Keshari; David M Wilson
Journal: Chem Soc Rev Date: 2013-12-20 Impact factor: 54.564