INTRODUCTION: Preeclamptic pregnancies induce concentric left ventricular hypertrophy instead of eccentric left ventricular hypertrophy as seen in healthy pregnancies. Although these differences persist for at least several months postpartum, the long-term fate of these changes is unknown. OBJECTIVE: To explore the age-related changes in cardiovascular structure and function in formerly preeclamptic women relative to parous controls. METHODS: A total of 20 formerly preeclamptic women and 8 parous controls underwent 2 echocardiograms at 1 and 14 years of postpartum. With the nonparametric Mann-Whitney U test and the Wilcoxon Signed Ranks test, we analyzed the between-group differences in cardiac structure and function at both time points and the time-related changes in these indices. RESULTS: Left ventricular geometry and dimensions and systolic function were comparable in the 2 study groups at both time points. The age-related decline in E/A ratio and increase in intraventricular septum thickness were noted in both groups over time, without appreciable differences between groups. CONCLUSION: A history of preeclampsia does not affect the age-related cardiac remodeling over a period of 14 years.
INTRODUCTION: Preeclamptic pregnancies induce concentric left ventricular hypertrophy instead of eccentric left ventricular hypertrophy as seen in healthy pregnancies. Although these differences persist for at least several months postpartum, the long-term fate of these changes is unknown. OBJECTIVE: To explore the age-related changes in cardiovascular structure and function in formerly preeclamptic women relative to parous controls. METHODS: A total of 20 formerly preeclamptic women and 8 parous controls underwent 2 echocardiograms at 1 and 14 years of postpartum. With the nonparametric Mann-Whitney U test and the Wilcoxon Signed Ranks test, we analyzed the between-group differences in cardiac structure and function at both time points and the time-related changes in these indices. RESULTS: Left ventricular geometry and dimensions and systolic function were comparable in the 2 study groups at both time points. The age-related decline in E/A ratio and increase in intraventricular septum thickness were noted in both groups over time, without appreciable differences between groups. CONCLUSION: A history of preeclampsia does not affect the age-related cardiac remodeling over a period of 14 years.
Authors: Maya Reddy; Leah Wright; Daniel Lorber Rolnik; Wentao Li; Ben Willem Mol; Andre La Gerche; Fabricio da SilvaCosta; Euan M Wallace; Kirsten Palmer Journal: J Am Heart Assoc Date: 2019-11-08 Impact factor: 5.501
Authors: Dawn C Scantlebury; Garvan C Kane; Heather J Wiste; Kent R Bailey; Stephen T Turner; Donna K Arnett; Richard B Devereux; Thomas H Mosley; Steven C Hunt; Alan B Weder; Beatriz Rodriguez; Eric Boerwinkle; Tracey L Weissgerber; Vesna D Garovic Journal: Heart Date: 2015-08-04 Impact factor: 5.994