Literature DB >> 23203183

Unilateral facial palsy in an infant: an unusual presentation of familial multiple cerebral cavernous malformation.

Zaitun Zakaria1, Chandrasekaran Kaliaperumal, John Caird, Mohammad Sattar.   

Abstract

Cerebral cavernous malformation (CCM) in infants tends to have genetic predisposition. These cavernomas have a progressive course of events and associated neurological symptoms with increase in age. They most commonly present with seizure and syndrome of increased intracranial pressure comprising of headache, vomiting and focal neurological signs. We describe a case of a 7-month-old infant who presented with an acute onset of right facial paralysis with a background of familial CCM. The CT and MRI scan revealed fresh haemorrhage in the right cerebellar and pontine cavernomas with surrounding oedema and no evidence of obstructive hydrocephalus. These two cavernomas re-bled in a week duration causing episodes of incessant crying and irritability. After discussing the pros and cons of treatment, owing to stable clinical status, the patient is currently been managed conservatively.

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Year:  2012        PMID: 23203183      PMCID: PMC4543825          DOI: 10.1136/bcr-2012-007508

Source DB:  PubMed          Journal:  BMJ Case Rep        ISSN: 1757-790X


  9 in total

1.  Spectrum of genotype and clinical manifestations in cerebral cavernous malformations.

Authors:  Judith Gault; Stephan Sain; Ling-Jia Hu; Issam A Awad
Journal:  Neurosurgery       Date:  2006-12       Impact factor: 4.654

2.  Intracranial cavernous hemangioma and seizures in a newborn infant.

Authors:  Muhammad Azam; Donough J O'Donovan
Journal:  J Pediatr       Date:  2009-08       Impact factor: 4.406

3.  Cerebral cavernous malformations: natural history and prognosis after clinical deterioration with or without hemorrhage.

Authors:  P J Porter; R A Willinsky; W Harper; M C Wallace
Journal:  J Neurosurg       Date:  1997-08       Impact factor: 5.115

4.  Genotype-phenotype correlations in cerebral cavernous malformations patients.

Authors:  Christian Denier; Pierre Labauge; Françoise Bergametti; Florence Marchelli; Florence Riant; Minh Arnoult; Jacqueline Maciazek; Eric Vicaut; Laurent Brunereau; Elisabeth Tournier-Lasserve
Journal:  Ann Neurol       Date:  2006-11       Impact factor: 10.422

Review 5.  Cavernous malformations of the brainstem in infants. Report of two cases and review of the literature.

Authors:  Bruno P Braga; Leodante B Costa; Sergio Lemos; Marcelo D Vilela
Journal:  J Neurosurg       Date:  2006-06       Impact factor: 5.115

Review 6.  Central nervous system cavernomas in the pediatric age group.

Authors:  C Mottolese; M Hermier; H Stan; A Jouvet; G Saint-Pierre; J C Froment; P Bret; C Lapras
Journal:  Neurosurg Rev       Date:  2001-07       Impact factor: 3.042

Review 7.  Familial cerebral cavernous haemangioma diagnosed in an infant with a rapidly growing cerebral lesion.

Authors:  B H K Ng; E Mulyadi; J K Pereira; S Ghedia; J Pinner; D Mowat; M Vonau
Journal:  Australas Radiol       Date:  2006-12

Review 8.  Giant posterior fossa cavernous malformations in 2 infants with familial cerebral cavernomatosis: the case for early screening.

Authors:  Sean M Lew
Journal:  Neurosurg Focus       Date:  2010-09       Impact factor: 4.047

9.  Management of pediatric brainstem cavernous malformations: experience over 20 years at the hospital for sick children.

Authors:  Ratan D Bhardwaj; Kurtis I Auguste; Abhaya V Kulkarni; Peter B Dirks; James M Drake; James T Rutka
Journal:  J Neurosurg Pediatr       Date:  2009-11       Impact factor: 2.375

  9 in total

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