AIM: In the present investigation, vancomycin (VCM) biodegradable nanoparticles were developed for oral administration, with the aim of improving its intestinal permeability. METHODS: The vancomycin-loaded nanoparticles were prepared using double-emulsion solvent evaporation method. The prepared nanoparticles were characterized for their micromeritic and crystallographic properties, particle size, zeta potential, drug loading and release. Intestinal permeability of VCM nanoparticles was determined in different concentrations using SPIP technique in rats. RESULTS: Particle sizes were between 450 nm and 466 nm for different compositions of VCM-PLGA nanoparticles. Entrapment efficiency ranged between 38.38% and 78.6% with negative zeta (ζ) potential. The FT-IR, XRPD and DSC results ruled out any chemical interaction between the drug and PLGA. Effective intestinal permeability values of VCM nanoparticles in concentrations of 200, 300 and 400 μg/ml were significantly higher than that of solutions at the same concentrations. CONCLUSION: Our findings suggest that PLGA nanoparticles could provide a delivery system for VCM, with enhanced intestinal permeability.
AIM: In the present investigation, vancomycin (VCM) biodegradable nanoparticles were developed for oral administration, with the aim of improving its intestinal permeability. METHODS: The vancomycin-loaded nanoparticles were prepared using double-emulsion solvent evaporation method. The prepared nanoparticles were characterized for their micromeritic and crystallographic properties, particle size, zeta potential, drug loading and release. Intestinal permeability of VCM nanoparticles was determined in different concentrations using SPIP technique in rats. RESULTS: Particle sizes were between 450 nm and 466 nm for different compositions of VCM-PLGA nanoparticles. Entrapment efficiency ranged between 38.38% and 78.6% with negative zeta (ζ) potential. The FT-IR, XRPD and DSC results ruled out any chemical interaction between the drug and PLGA. Effective intestinal permeability values of VCM nanoparticles in concentrations of 200, 300 and 400 μg/ml were significantly higher than that of solutions at the same concentrations. CONCLUSION: Our findings suggest that PLGA nanoparticles could provide a delivery system for VCM, with enhanced intestinal permeability.
Authors: Jessica García-Melero; Joan-Josep López-Mitjavila; María José García-Celma; Carlos Rodriguez-Abreu; Santiago Grijalvo Journal: Materials (Basel) Date: 2022-06-29 Impact factor: 3.748
Authors: Elzaan Booysen; Hanél Sadie-Van Gijsen; Shelly M Deane; William Ferris; Leon M T Dicks Journal: Probiotics Antimicrob Proteins Date: 2019-09 Impact factor: 4.609
Authors: Samet Ucak; Mert Sudagidan; Baris A Borsa; Banu Mansuroglu; Veli C Ozalp Journal: World J Microbiol Biotechnol Date: 2020-04-25 Impact factor: 3.312
Authors: Elzaan Booysen; Martin Bezuidenhout; Anton Du Preez van Staden; Dimiter Dimitrov; Shelly M Deane; Leon M T Dicks Journal: Probiotics Antimicrob Proteins Date: 2019-03 Impact factor: 4.609