Literature DB >> 23198976

Meaningful cut-off pain intensity for breakthrough pain changes in advanced cancer patients.

Sebastiano Mercadante1, Claudio Adile, Riccardo Torta, Antonella Varetto, Fabio Fulfaro, Antonino Giarratano, Alessandra Casuccio.   

Abstract

OBJECTIVES: To assess the level of pain intensity at which patients feel the impetus to ask for a breakthrough cancer pain (BTcP) medication, and level of pain intensity at which patients consider they have achieved acceptable pain control after receiving a BTcP medication.
METHODS: A consecutive sample of patients who were receiving oral morphine equivalents equal to or more than 60 mg daily, and were prescribed rapid onset opioids for the management of episodes of BTcP, were included in the study. Focused educational activities regarding BTcP and numerical scales were established during hospital admission. At discharge patients were interviewed to find out what was the pain intensity level which gave the impetus to take the BTcP medication, what was the pain intensity for acceptable pain control after a BTcP medication had been given, and which factors prevented the patient calling for BTcP medication. A brief COPE (coping orientation to problems experienced) questionnaire was also administered.
RESULTS: Fifty-two patients were recruited for this study. The meaningful pain intensity for asking for a BTcP medication was 7.1; 77% of patients had a pain intensity of 7-8 on a numerical scale of 0-10. The meaningful pain intensity for adequate analgesia after a BTcP medication was 3.5. Similarly, 77% of patients had a pain intensity of 3-4. There was no relationship with the variables examined. Concerns by patients about the use of BTcP medications were minimal.
CONCLUSION: The meaningful BTcP intensity and pain intensity expected after BTcP medication can be useful in selecting patients in studies of BTcP. The principal limitation of this study was the specific setting of an acute unit with specific features and the relatively low number of patients. This observation should be followed up by further surveys with a larger number of patients and different settings.

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Year:  2012        PMID: 23198976     DOI: 10.1185/03007995.2012.755120

Source DB:  PubMed          Journal:  Curr Med Res Opin        ISSN: 0300-7995            Impact factor:   2.580


  10 in total

1.  Understanding the Chameleonic Breakthrough Cancer Pain.

Authors:  Sebastiano Mercadante; Russell K Portenoy
Journal:  Drugs       Date:  2021-01-30       Impact factor: 9.546

2.  The use of low doses of a sublingual fentanyl formulation for breakthrough pain in patients receiving low doses of opioids.

Authors:  Sebastiano Mercadante; Claudio Adile; Arturo Cuomo; Federica Aielli; Franco Marinangeli; Alessandra Casuccio
Journal:  Support Care Cancer       Date:  2016-10-15       Impact factor: 3.603

Review 3.  Breakthrough pain and its treatment: critical review and recommendations of IOPS (Italian Oncologic Pain Survey) expert group.

Authors:  Sebastiano Mercadante; Paolo Marchetti; Arturo Cuomo; Massimo Mammucari; Augusto Caraceni
Journal:  Support Care Cancer       Date:  2015-10-05       Impact factor: 3.603

4.  Breakthrough Cancer Pain: Preliminary Data of The Italian Oncologic Pain Multisetting Multicentric Survey (IOPS-MS).

Authors:  Sebastiano Mercadante; Paolo Marchetti; Arturo Cuomo; Augusto Caraceni; Rocco Domenico Mediati; Massimo Mammucari; Silvia Natoli; Marzia Lazzari; Mario Dauri; Mario Airoldi; Giuseppe Azzarello; Mauro Bandera; Livio Blasi; Giacomo Cartenì; Bruno Chiurazzi; Benedetta Veruska Pierpaola Costanzo; Daniela Degiovanni; Flavio Fusco; Vittorio Guardamagna; Vincenzo Iaffaioli; Simeone Liguori; Vito Lorusso; Sergio Mameli; Rodolfo Mattioli; Teresita Mazzei; Rita Maria Melotti; Valentino Menardo; Danilo Miotti; Stefano Moroso; Stefano De Santis; Remo Orsetti; Alfonso Papa; Sergio Ricci; Alessandro Fabrizio Sabato; Elvira Scelzi; Michele Sofia; Giuseppe Tonini; Federica Aielli; Alessandro Valle
Journal:  Adv Ther       Date:  2016-11-21       Impact factor: 3.845

Review 5.  Pain relief that matters to patients: systematic review of empirical studies assessing the minimum clinically important difference in acute pain.

Authors:  Mette Frahm Olsen; Eik Bjerre; Maria Damkjær Hansen; Jørgen Hilden; Nino Emanuel Landler; Britta Tendal; Asbjørn Hróbjartsson
Journal:  BMC Med       Date:  2017-02-20       Impact factor: 8.775

6.  Factors Influencing the Clinical Presentation of Breakthrough Pain in Cancer Patients.

Authors:  Sebastiano Mercadante; Paolo Marchetti; Arturo Cuomo; Augusto Caraceni; Rocco Domenico Mediati; Renato Vellucci; Massimo Mammucari; Silvia Natoli; Marzia Lazzari; Mario Dauri; Claudio Adile; Mario Airoldi; Giuseppe Azzarello; Mauro Bandera; Livio Blasi; Giacomo Cartenì; Bruno Chiurazzi; Benedetta Veruska Pierpaola Costanzo; Daniela Degiovanni; Flavio Fusco; Vittorio Guardamagna; Vincenzo Iaffaioli; Simeone Liguori; Loredana Palermo; Sergio Mameli; Francesco Masedu; Rodolfo Mattioli; Teresita Mazzei; Rita Maria Melotti; Valentino Menardo; Danilo Miotti; Stefano Moroso; Gaetano Pascoletti; Stefano De Santis; Remo Orsetti; Alfonso Papa; Sergio Ricci; Elvira Scelzi; Michele Sofia; Giuseppe Tonini; Alessandro Valle; Federica Aielli
Journal:  Cancers (Basel)       Date:  2018-06-01       Impact factor: 6.639

7.  Pain Intensity Factors Changing Breakthrough Pain Prevalence in Patients with Advanced Cancer: A Secondary Analysis of a Cross-Sectional Observational International Study.

Authors:  Erik Torbjørn Løhre; Marianne Jensen Hjermstad; Cinzia Brunelli; Anne Kari Knudsen; Stein Kaasa; Pål Klepstad
Journal:  Pain Ther       Date:  2018-11-10

8.  Working towards a consensus on the oncological approach of breakthrough pain: a Delphi survey of Spanish experts.

Authors:  Carlos Camps Herrero; Antonio Antón Torres; Juan Jesús Cruz-Hernández; Alfredo Carrato; Manuel Constenla; Eduardo Díaz-Rubio; Margarita Feyjoo Saus; Jesus Garcia-Foncillas; Pere Gascón; Vicente Guillem
Journal:  J Pain Res       Date:  2019-07-29       Impact factor: 3.133

9.  Oxycodone/Acetaminophen: The Tailoring Combination Treatment for Specific Clinical Profile of Opioid Well-Responsive Cancer Pain.

Authors:  Stefano De Santis; Maria Domenica Simone; Sebastiano Mercadante; Rocco Domenico Mediati; Renato Vellucci; Paolo Marchetti; Giuseppe Tonini; Arturo Cuomo; Augusto Caraceni; Silvia Natoli; Grazia Armento; Livio Blasi; Massimo Mammucari
Journal:  Cancer Manag Res       Date:  2021-02-19       Impact factor: 3.989

10.  A systematic review of the risk factors for clinical response to opioids for all-age patients with cancer-related pain and presentation of the paediatric STOP pain study.

Authors:  Ersilia Lucenteforte; Laura Vagnoli; Alessandra Pugi; Giada Crescioli; Niccolò Lombardi; Roberto Bonaiuti; Maurizio Aricò; Sabrina Giglio; Andrea Messeri; Alessandro Mugelli; Alfredo Vannacci; Valentina Maggini
Journal:  BMC Cancer       Date:  2018-05-18       Impact factor: 4.430

  10 in total

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