Literature DB >> 23197635

Steering a new course for stem cell research: NIH's intramural Center for Regenerative Medicine.

Mahendra S Rao1, Francis S Collins.   

Abstract

The phenomenal progress made in stem cell biology in the past few years has infused the field of regenerative medicine with a great deal of scientific enthusiasm. However, along with the excitement of discovery comes a new sense of translational urgency. The prospect of using embryonic and induced pluripotent stem cell tools and technologies to produce cell-based therapies and other treatments is no longer a distant dream; it is a very real opportunity that demands our attention today. As with most new fields, regenerative medicine has experienced some significant growing pains, and we have identified a number of key obstacles to progress. Given our role as the lead U.S. biomedical research agency and the world's largest supporter of medical research, the National Institutes of Health (NIH) has a responsibility to find ways to reduce or remove many of these obstacles and, consequently, has-and continues-to respond to these challenges in a variety of ways. In this brief essay, we will review our progress and highlight a new development: the founding of a Center for Regenerative Medicine on the NIH campus.

Entities:  

Mesh:

Year:  2012        PMID: 23197635      PMCID: PMC3727682          DOI: 10.5966/sctm.2011-0032

Source DB:  PubMed          Journal:  Stem Cells Transl Med        ISSN: 2157-6564            Impact factor:   6.940


  7 in total

Review 1.  Guidelines and techniques for the generation of induced pluripotent stem cells.

Authors:  Nimet Maherali; Konrad Hochedlinger
Journal:  Cell Stem Cell       Date:  2008-12-04       Impact factor: 24.633

2.  Reengineering translational science: the time is right.

Authors:  Francis S Collins
Journal:  Sci Transl Med       Date:  2011-07-06       Impact factor: 17.956

3.  Immunogenicity of induced pluripotent stem cells.

Authors:  Tongbiao Zhao; Zhen-Ning Zhang; Zhili Rong; Yang Xu
Journal:  Nature       Date:  2011-05-13       Impact factor: 49.962

4.  Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.

Authors:  Kazutoshi Takahashi; Shinya Yamanaka
Journal:  Cell       Date:  2006-08-10       Impact factor: 41.582

5.  Induced pluripotent stem cells generated without viral integration.

Authors:  Matthias Stadtfeld; Masaki Nagaya; Jochen Utikal; Gordon Weir; Konrad Hochedlinger
Journal:  Science       Date:  2008-09-25       Impact factor: 47.728

6.  Human induced pluripotent stem cells free of vector and transgene sequences.

Authors:  Junying Yu; Kejin Hu; Kim Smuga-Otto; Shulan Tian; Ron Stewart; Igor I Slukvin; James A Thomson
Journal:  Science       Date:  2009-03-26       Impact factor: 47.728

7.  Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA.

Authors:  Luigi Warren; Philip D Manos; Tim Ahfeldt; Yuin-Han Loh; Hu Li; Frank Lau; Wataru Ebina; Pankaj K Mandal; Zachary D Smith; Alexander Meissner; George Q Daley; Andrew S Brack; James J Collins; Chad Cowan; Thorsten M Schlaeger; Derrick J Rossi
Journal:  Cell Stem Cell       Date:  2010-09-30       Impact factor: 24.633

  7 in total
  7 in total

1.  The stem cell wars: a dispatch from the front.

Authors:  Allen M Spiegel
Journal:  Trans Am Clin Climatol Assoc       Date:  2013

2.  National Institutes of Health Center for Regenerative Medicine: putting science into practice.

Authors:  Mahendra Rao
Journal:  Stem Cells Dev       Date:  2013-12       Impact factor: 3.272

3.  Harmonizing standards for producing clinical-grade therapies from pluripotent stem cells.

Authors:  Peter W Andrews; Joy Cavagnaro; Joy Cavanagro; Robert Deans; Ellen Feigal; Ellen Feigel; Ed Horowitz; Armand Keating; Mahendra Rao; Marc Turner; Ian Wilmut; Shinya Yamanaka
Journal:  Nat Biotechnol       Date:  2014-08       Impact factor: 54.908

4.  Dental, Oral, and Craniofacial Regenerative Medicine: Transforming Biotechnologies for Innovating Patient Care.

Authors:  W V Giannobile; Y Chai; Y Chen; K E Healy; O Klein; N Lane; M T Longaker; J C Lotz; D J Mooney; C S Sfeir; M Urata; W R Wagner; B M Wu; D H Kohn
Journal:  J Dent Res       Date:  2018-04       Impact factor: 6.116

Review 5.  Bioenergetics and metabolism: a bench to bedside perspective.

Authors:  Russell H Swerdlow
Journal:  J Neurochem       Date:  2016-03-10       Impact factor: 5.372

6.  Specimen collection for induced pluripotent stem cell research: harmonizing the approach to informed consent.

Authors:  Justin Lowenthal; Scott Lipnick; Mahendra Rao; Sara Chandros Hull
Journal:  Stem Cells Transl Med       Date:  2012-05-08       Impact factor: 6.940

Review 7.  "Model t" cells: a time-tested vehicle for gene therapy.

Authors:  Sid P Kerkar
Journal:  Front Immunol       Date:  2013-09-27       Impact factor: 7.561

  7 in total

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