Literature DB >> 23197020

Phase I trials of targeted anticancer drugs: a need to refocus.

Ernest C Borden1, Afshin Dowlati.   

Abstract

As cancer therapy progresses through the development of molecularly targeted drugs, the focus of Phase I trials needs to shift towards investigating end points that could guide more effective trial design, dosing and choice of tumour setting for Phase II studies.

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Year:  2012        PMID: 23197020     DOI: 10.1038/nrd3909

Source DB:  PubMed          Journal:  Nat Rev Drug Discov        ISSN: 1474-1776            Impact factor:   84.694


  4 in total

Review 1.  Targeted agents: how to select the winners in preclinical and early clinical studies?

Authors:  Rachel Goodwin; Giuseppe Giaccone; Hilary Calvert; Marinus Lobbezoo; Elizabeth A Eisenhauer
Journal:  Eur J Cancer       Date:  2011-11-15       Impact factor: 9.162

Review 2.  Phase 0 clinical trials: recommendations from the Task Force on Methodology for the Development of Innovative Cancer Therapies.

Authors:  Shivaani Kummar; James H Doroshow; Joseph E Tomaszewski; A Hilary Calvert; Marinus Lobbezoo; Giuseppe Giaccone
Journal:  Eur J Cancer       Date:  2008-12-16       Impact factor: 9.162

Review 3.  Biomarkers in early cancer drug development: limited utility.

Authors:  R H Glassman; M J Ratain
Journal:  Clin Pharmacol Ther       Date:  2009-02       Impact factor: 6.875

Review 4.  Dose escalation methods in phase I cancer clinical trials.

Authors:  Christophe Le Tourneau; J Jack Lee; Lillian L Siu
Journal:  J Natl Cancer Inst       Date:  2009-05-12       Impact factor: 13.506

  4 in total
  1 in total

1.  Metrics other than potency reveal systematic variation in responses to cancer drugs.

Authors:  Mohammad Fallahi-Sichani; Saman Honarnejad; Laura M Heiser; Joe W Gray; Peter K Sorger
Journal:  Nat Chem Biol       Date:  2013-09-08       Impact factor: 15.040

  1 in total

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