Laura Stertz1, Pedro V S Magalhães, Flávio Kapczinski. 1. Laboratory of Molecular Psychiatry, Centro de Pesquisas Experimentais, Hospital de Clínicas de Porto Alegre, and INCT for Translational Medicine, Brazil.
Abstract
PURPOSE OF REVIEW: Literature published over the past few years indicates that bipolar disorder has an inflammatory component but does not explicitly define bipolar disorder as an inflammatory or a noninflammatory condition. RECENT FINDINGS: Recent studies have shown that bipolar disorder involves microglial activation and alterations in peripheral cytokines and have pointed to the efficacy of adjunctive anti-inflammatory therapies in bipolar depression. SUMMARY: The presence of active microglia and increased proinflammatory cytokines in bipolar disorder suggests an important role of inflammatory components in the pathophysiology of the disease, as well as a possible link between neuroinflammation and peripheral toxicity.
PURPOSE OF REVIEW: Literature published over the past few years indicates that bipolar disorder has an inflammatory component but does not explicitly define bipolar disorder as an inflammatory or a noninflammatory condition. RECENT FINDINGS: Recent studies have shown that bipolar disorder involves microglial activation and alterations in peripheral cytokines and have pointed to the efficacy of adjunctive anti-inflammatory therapies in bipolar depression. SUMMARY: The presence of active microglia and increased proinflammatory cytokines in bipolar disorder suggests an important role of inflammatory components in the pathophysiology of the disease, as well as a possible link between neuroinflammation and peripheral toxicity.
Authors: Ting He; Michelle S Itano; Lauriel F Earley; Nikita E Hall; Natallia Riddick; R Jude Samulski; Chengwen Li Journal: Hum Gene Ther Clin Dev Date: 2019-12 Impact factor: 5.032
Authors: Hasan Mayda; Ahmet Ahsen; Erman Bağcioğlu; Ahmet Öztürk; Bülent Bahçeci; Etem Soyuçok; Erol Başpinar; Memnune Sena Ulu Journal: Noro Psikiyatr Ars Date: 2016-12-01 Impact factor: 1.339