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Literature DB >> 23196842

Hippo-YAP and mTOR pathways collaborate to regulate organ size.

Abstract

Regulation of organ size is achieved through the action of the mTOR and Hippo signalling pathways, which control cell proliferation and cell growth in response to extracellular cues. A link between these pathways is revealed by the finding that YAP downregulates PTEN to promote cell growth and tissue hyperplasia.

Entities: Disease Gene

Mesh：

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Year: 2012 PMID： 23196842 DOI： 10.1038/ncb2634

Source DB: PubMed Journal: Nat Cell Biol ISSN： 1465-7392 Impact factor: 28.824

15 in total

1. Metabolic stress controls mTORC1 lysosomal localization and dimerization by regulating the TTT-RUVBL1/2 complex.

Authors: Sang Gyun Kim; Gregory R Hoffman; George Poulogiannis; Gwen R Buel; Young Jin Jang; Ki Won Lee; Bo-Yeon Kim; Raymond L Erikson; Lewis C Cantley; Andrew Y Choo; John Blenis
Journal: Mol Cell Date: 2012-11-08 Impact factor: 17.970

2. Akt is negatively regulated by Hippo signaling for growth inhibition in Drosophila.

Authors: Xin Ye; Yaoting Deng; Zhi-Chun Lai
Journal: Dev Biol Date: 2012-06-23 Impact factor: 3.582

3. Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids.

Authors: Yasemin Sancak; Liron Bar-Peled; Roberto Zoncu; Andrew L Markhard; Shigeyuki Nada; David M Sabatini
Journal: Cell Date: 2010-04-08 Impact factor: 41.582

4. Insulin/IGF signaling drives cell proliferation in part via Yorkie/YAP.

Authors: Katrin Straßburger; Marcel Tiebe; Federico Pinna; Kai Breuhahn; Aurelio A Teleman
Journal: Dev Biol Date: 2012-05-16 Impact factor: 3.582

5. YAP mediates crosstalk between the Hippo and PI(3)K–TOR pathways by suppressing PTEN via miR-29.

Authors: Karen Tumaneng; Karin Schlegelmilch; Ryan C Russell; Dean Yimlamai; Harihar Basnet; Navin Mahadevan; Julien Fitamant; Nabeel Bardeesy; Fernando D Camargo; Kun-Liang Guan
Journal: Nat Cell Biol Date: 2012-12 Impact factor: 28.824

Review 6. The Hippo signaling pathway and stem cell biology.

Authors: Azucena Ramos; Fernando D Camargo
Journal: Trends Cell Biol Date: 2012-05-31 Impact factor: 20.808

7. AMPK phosphorylation of raptor mediates a metabolic checkpoint.

Authors: Dana M Gwinn; David B Shackelford; Daniel F Egan; Maria M Mihaylova; Annabelle Mery; Debbie S Vasquez; Benjamin E Turk; Reuben J Shaw
Journal: Mol Cell Date: 2008-04-25 Impact factor: 17.970

Review 8. Molecular mechanisms of mTOR-mediated translational control.

Authors: Xiaoju Max Ma; John Blenis
Journal: Nat Rev Mol Cell Biol Date: 2009-04-02 Impact factor: 94.444

Review 9. Organ size control by Hippo and TOR pathways.

Authors: Karen Tumaneng; Ryan C Russell; Kun-Liang Guan
Journal: Curr Biol Date: 2012-05-07 Impact factor: 10.834

Review 10. The hippo signaling pathway in development and cancer.

Authors: Duojia Pan
Journal: Dev Cell Date: 2010-10-19 Impact factor: 12.270

37 in total

1. SAV1 represses the development of human colorectal cancer by regulating the Akt-mTOR pathway in a YAP-dependent manner.

Authors: Jianwu Jiang; Wei Chang; Yang Fu; Yongshun Gao; Chunlin Zhao; Xiefu Zhang; Shuijun Zhang
Journal: Cell Prolif Date: 2017-06-15 Impact factor: 6.831

2. Phosphorylation of the Hippo Pathway Component AMOTL2 by the mTORC2 Kinase Promotes YAP Signaling, Resulting in Enhanced Glioblastoma Growth and Invasiveness.

Authors: Nicholas Artinian; Cheri Cloninger; Brent Holmes; Angelica Benavides-Serrato; Tariq Bashir; Joseph Gera
Journal: J Biol Chem Date: 2015-05-21 Impact factor: 5.157

Hippo-YAP and mTOR pathways collaborate to regulate organ size.

1. Metabolic stress controls mTORC1 lysosomal localization and dimerization by regulating the TTT-RUVBL1/2 complex.

2. Akt is negatively regulated by Hippo signaling for growth inhibition in Drosophila.

3. Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids.

4. Insulin/IGF signaling drives cell proliferation in part via Yorkie/YAP.

5. YAP mediates crosstalk between the Hippo and PI(3)K–TOR pathways by suppressing PTEN via miR-29.

Review 6. The Hippo signaling pathway and stem cell biology.

7. AMPK phosphorylation of raptor mediates a metabolic checkpoint.

Review 8. Molecular mechanisms of mTOR-mediated translational control.

Review 9. Organ size control by Hippo and TOR pathways.

Review 10. The hippo signaling pathway in development and cancer.

1. SAV1 represses the development of human colorectal cancer by regulating the Akt-mTOR pathway in a YAP-dependent manner.

2. Phosphorylation of the Hippo Pathway Component AMOTL2 by the mTORC2 Kinase Promotes YAP Signaling, Resulting in Enhanced Glioblastoma Growth and Invasiveness.

3. Phosphorylated mTOR and YAP serve as prognostic markers and therapeutic targets in gliomas.

4. Inhibition of YAP with siRNA prevents cartilage degradation and ameliorates osteoarthritis development.

5. Yap/Taz mediates mTORC2-stimulated fibroblast activation and kidney fibrosis.

6. Simulated microgravity increases polyploid giant cancer cells and nuclear localization of YAP.

7. Yes-associated protein (YAP) promotes cell survival by inhibiting proapoptotic dendrin signaling.

8. The hippo pathway is activated and is a causal mechanism for adipogenesis in arrhythmogenic cardiomyopathy.

9. Hippo and Hyperplasia.

10. Loss of ANCO1 repression at AIB1/YAP targets drives breast cancer progression.