Literature DB >> 231967

Expression of galactose-1-p-uridyltransferase in Chinese hamster x human galactosemia somatic cell hybrids.

R S Sparkes, T Mohandas, M C Sparkes, J D Shulkin.   

Abstract

Lymphocytes from a patient with classic galactosemia (GALT deficiency) were hybridized with a Chinese hamster cell line. Electrophoretic valuation of GALT in 31 independently derived interspecific hybrid clones failed to demonstrate expression of the human GALT gene even when human chromosome 9 was present. Possible mechanisms for this lack of expression are presented.

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Year:  1979        PMID： 231967     DOI： 10.1007/bf00502126

Source DB:  PubMed          Journal:  Biochem Genet        ISSN： 0006-2928            Impact factor:   1.890


  20 in total

1.  Differential binding of alkylating fluorochromes in human chromosomes.

Authors:  T Caspersson; L Zech; C Johansson
Journal:  Exp Cell Res       Date:  1970-06       Impact factor: 3.905

2.  Correction of human mucolipidosis II enzyme abnormalities in somatic cell hybrids.

Authors:  M J Champion; T B Shows
Journal:  Nature       Date:  1977-11-03       Impact factor: 49.962

3.  Purification of normal and inactive galactosemic galactose-1-phosphate uridylyltransferase from human red cells.

Authors:  G L Dale; G Popják
Journal:  J Biol Chem       Date:  1976-02-25       Impact factor: 5.157

4.  Assignment of the AK1:Np:ABO linkage group to human chromosome 9.

Authors:  A Westerveld; A P Jongsma; P Meera Khan; H van Someren; D Bootsma
Journal:  Proc Natl Acad Sci U S A       Date:  1976-03       Impact factor: 11.205

5.  Genetically determined variation of adenylate kinase in man.

Authors:  R A Fildes; H Harris
Journal:  Nature       Date:  1966-01-15       Impact factor: 49.962

6.  A study of hexosaminadases in interspecific hybrids and in GM2 gangliosidosis with a discussion on their genetic control.

Authors:  N Van Cong; D Weil; R Rebourcet; J Frézal; A M Richard-Mollard
Journal:  Ann Hum Genet       Date:  1975-07       Impact factor: 1.670

7.  Galactosemia: evidence for a structural gene mutation.

Authors:  T A Tedesco; W J Mellman
Journal:  Science       Date:  1971-05-14       Impact factor: 47.728

8.  Characterization of residual hexosaminidase activity in Sandhoff's disease using man-Chinese hamster cell hybrids.

Authors:  H L Hoeksema; A J Reuser; A T Hoogeveen; A Westerveld; H Galjaard
Journal:  Hum Genet       Date:  1977-12-23       Impact factor: 4.132

9.  Interallelic complementation in hybrid cells derived from human diploid strains deficient in galactose-1-phosphate uridyl transferase activity.

Authors:  H L Nadler; C M Chacko; M Rachmeler
Journal:  Proc Natl Acad Sci U S A       Date:  1970-10       Impact factor: 11.205

10.  Aconitase polymorphism in man.

Authors:  C A Slaughter; D A Hopkinson; H Harris
Journal:  Ann Hum Genet       Date:  1975-10       Impact factor: 1.670
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