O Svejme1, H G Ahlborg, M K Karlsson. 1. Clinical and Molecular Osteoporosis Research Unit, Department of Clinical Sciences and Orthopaedics, Lund University, Department of Orthopaedics, Skane University Hospital, Malmo, Sweden. ola.svejme@med.lu.se
Abstract
OBJECTIVE: Bone loss and periosteal expansion is found after menopause. The accelerated early postmenopausal bone loss is not permanent but if the same accounts for the periosteal expansion is unknown. METHODS: Bone mineral density (BMD) and skeletal structure of the distal forearm were followed from menopause and on average 24 years (range 18-28) by single-photon absorptiometry at 12 occasions in a population-based sample of 81 Caucasian women with no medication or disease affecting bone metabolism. A Strength Index based on areal BMD and bone structure was calculated. Postmenopausal serum-estradiol levels and incident distal radius fractures were registered. Data are presented as means with 95% confidence interval (95% CI). RESULTS: The annual BMD loss in three periods, 0-8, 8-16 and 16-28 years after menopause, was 2.0% (1.6, 2.4), 1.0% (0.6, 1.4) and 1.0% (0.7, 1.3), respectively. The annual periosteal expansion was 1.0% (0.8, 1.3), 0.0% (-0.3, 0.3) and 0.0% (-0.2, 0.2), respectively. Mean post-menopausal oestrogen levels correlated moderately with annual loss in aBMD (r=0.51, p<0.001) but less with the annual changes in bone width (r= -0.22, p=0.06). CONCLUSION: Postmenopausal periosteal expansion in the distal forearm seems to occur only in the first postmenopausal decade.
OBJECTIVE: Bone loss and periosteal expansion is found after menopause. The accelerated early postmenopausal bone loss is not permanent but if the same accounts for the periosteal expansion is unknown. METHODS: Bone mineral density (BMD) and skeletal structure of the distal forearm were followed from menopause and on average 24 years (range 18-28) by single-photon absorptiometry at 12 occasions in a population-based sample of 81 Caucasian women with no medication or disease affecting bone metabolism. A Strength Index based on areal BMD and bone structure was calculated. Postmenopausal serum-estradiol levels and incident distal radius fractures were registered. Data are presented as means with 95% confidence interval (95% CI). RESULTS: The annual BMD loss in three periods, 0-8, 8-16 and 16-28 years after menopause, was 2.0% (1.6, 2.4), 1.0% (0.6, 1.4) and 1.0% (0.7, 1.3), respectively. The annual periosteal expansion was 1.0% (0.8, 1.3), 0.0% (-0.3, 0.3) and 0.0% (-0.2, 0.2), respectively. Mean post-menopausal oestrogen levels correlated moderately with annual loss in aBMD (r=0.51, p<0.001) but less with the annual changes in bone width (r= -0.22, p=0.06). CONCLUSION: Postmenopausal periosteal expansion in the distal forearm seems to occur only in the first postmenopausal decade.
Authors: Lara Terra; Maartje J Hooning; Bernadette A M Heemskerk-Gerritsen; Marc van Beurden; Jeanine E Roeters van Lennep; Helena C van Doorn; Joanne A de Hullu; Constantijne Mom; Eleonora B L van Dorst; Marian J E Mourits; Brigitte F M Slangen; Katja N Gaarenstroom; M Carola Zillikens; Tim Leiner; Lizet van der Kolk; Margriet Collee; Marijke Wevers; Margreet G E M Ausems; Klaartje van Engelen; Lieke Pv Berger; Christi J van Asperen; Encarna B Gomez-Garcia; Irma van de Beek; Matti A Rookus; Michael Hauptmann; Eveline M Bleiker; Sanne B Schagen; Neil K Aaronson; Angela H E M Maas; Flora E van Leeuwen Journal: JMIR Res Protoc Date: 2021-01-22