Kim Cocks1, David J Torgerson. 1. York Trials Unit, Department of Health Sciences, University of York, Heslington, York YO10 5DD, UK.
Abstract
OBJECTIVES: To describe a method using confidence intervals (CIs) to estimate the sample size for a pilot randomized trial. STUDY DESIGN: Using one-sided CIs and the estimated effect size that would be sought in a large trial, we calculated the sample size needed for pilot trials. RESULTS: Using an 80% one-sided CI, we estimated that a pilot trial should have at least 9% of the sample size of the main planned trial. CONCLUSION: Using the estimated effect size difference for the main trial and using a one-sided CI, this allows us to calculate a sample size for a pilot trial, which will make its results more useful than at present.
RCT Entities:
OBJECTIVES: To describe a method using confidence intervals (CIs) to estimate the sample size for a pilot randomized trial. STUDY DESIGN: Using one-sided CIs and the estimated effect size that would be sought in a large trial, we calculated the sample size needed for pilot trials. RESULTS: Using an 80% one-sided CI, we estimated that a pilot trial should have at least 9% of the sample size of the main planned trial. CONCLUSION: Using the estimated effect size difference for the main trial and using a one-sided CI, this allows us to calculate a sample size for a pilot trial, which will make its results more useful than at present.
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