Cardioactive iridoid glycosides from Eremophila species.

Four iridoid glycosides isolated from different species of Eremophila (Myoporaceae) were tested for their effects on the Langendorff rat heart. Melampyroside (1), verminoside (2), ferruloylajugol (3) and catalpol (4) all significantly decreased contractile force in the isolated rat heart test. Within a minute after administration all, except catalpol, significantly increased heart rate and coronary perfusion rate. These results are compared to those of other cardioactive iridoid glycosides described in the literature. Copyright © 1997 Gustav Fischer Verlag. Published by Elsevier GmbH.. All rights reserved.