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Literature DB >> 23195533

Environmental pH-sensitive polymeric micelles for cancer diagnosis and targeted therapy.

Abstract

The delivery and control over the release of hydrophobic imaging markers for cancer diagnosis or pharmaceutical agents for targeted therapy are of considerable interest. Nano-sized pH-sensitive polymeric micelles that rely on the enhanced permeability and retention (EPR) of vasculature and the low-pH microenvironment in cancer tissue are emerging as stimuli-responsive targeted therapies that can simultaneously release diagnostic and therapeutic agents into a cancerous region. This review focuses on the developments of pH-sensitive polymeric micelles and their biomedical applications in cancer diagnosis and targeted therapy.

Entities: Disease

Mesh：

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Year: 2012 PMID： 23195533 DOI： 10.1016/j.jconrel.2012.11.012

Source DB: PubMed Journal: J Control Release ISSN： 0168-3659 Impact factor: 9.776

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Cited

26 in total

Review 1. Degradable Controlled-Release Polymers and Polymeric Nanoparticles: Mechanisms of Controlling Drug Release.

Authors: Nazila Kamaly; Basit Yameen; Jun Wu; Omid C Farokhzad
Journal: Chem Rev Date: 2016-02-08 Impact factor: 60.622

Review 2. Stromal barriers and strategies for the delivery of nanomedicine to desmoplastic tumors.

Authors: Lei Miao; C Michael Lin; Leaf Huang
Journal: J Control Release Date: 2015-08-12 Impact factor: 9.776

Review 3. Chemotherapy targeting cancer stem cells.

Authors: Haiguang Liu; Lin Lv; Kai Yang
Journal: Am J Cancer Res Date: 2015-02-15 Impact factor: 6.166

Review 4. Systemic delivery to central nervous system by engineered PLGA nanoparticles.

Authors: Qiang Cai; Long Wang; Gang Deng; Junhui Liu; Qianxue Chen; Zhibiao Chen
Journal: Am J Transl Res Date: 2016-02-15 Impact factor: 4.060

5. Acidic pH-Triggered Drug-Eluting Nanocomposites for Magnetic Resonance Imaging-Monitored Intra-arterial Drug Delivery to Hepatocellular Carcinoma.

Authors: Wooram Park; Jeane Chen; Soojeong Cho; Sin-Jung Park; Andrew C Larson; Kun Na; Dong-Hyun Kim
Journal: ACS Appl Mater Interfaces Date: 2016-05-16 Impact factor: 9.229

6. Biodegradable Polymersomes as Nanocarriers for Doxorubicin Hydrochloride: Enhanced Cytotoxicity in MCF-7/ADR Cells and Prolonged Blood Circulation.

Authors: Yanhui Chao; Yuheng Liang; Guihua Fang; Haibing He; Qing Yao; Hang Xu; Yinrong Chen; Xing Tang
Journal: Pharm Res Date: 2016-12-21 Impact factor: 4.200

Environmental pH-sensitive polymeric micelles for cancer diagnosis and targeted therapy.

Review 1. Degradable Controlled-Release Polymers and Polymeric Nanoparticles: Mechanisms of Controlling Drug Release.

Review 2. Stromal barriers and strategies for the delivery of nanomedicine to desmoplastic tumors.

Review 3. Chemotherapy targeting cancer stem cells.

Review 4. Systemic delivery to central nervous system by engineered PLGA nanoparticles.

5. Acidic pH-Triggered Drug-Eluting Nanocomposites for Magnetic Resonance Imaging-Monitored Intra-arterial Drug Delivery to Hepatocellular Carcinoma.

6. Biodegradable Polymersomes as Nanocarriers for Doxorubicin Hydrochloride: Enhanced Cytotoxicity in MCF-7/ADR Cells and Prolonged Blood Circulation.

Review 7. Polymer-Based and pH-Sensitive Nanobiosensors for Imaging and Therapy of Acidic Pathological Areas.

Review 8. Molecular imaging of the tumor microenvironment for precision medicine and theranostics.

9. Size-Dependent EPR Effect of Polymeric Nanoparticles on Tumor Targeting.

Review 10. Reduction-responsive polymeric micelles and vesicles for triggered intracellular drug release.