L-DOPA- and graft-induced dyskinesia following transplantation.

Recent clinical and preclinical data are shedding greater light on the nuances of transplantation of fetal tissue for the treatment of Parkinson's disease. The field was brought to a halt by the development of abnormal involuntary movements directly linked to the graft at the turn of the century. Since then, there has been further analysis of transplanted patients, the development of an animal model, and extensive preclinical experimentation to clarify the activity of the graft and examine closely its interactions with the host environment and the direct consequences for L-DOPA- and graft-induced dyskinesia. This review brings together the latest clinical and preclinical findings on the impact of transplantation on both L-DOPA- and graft-induced dyskinesia.