Literature DB >> 23195314

Genetic and molecular network analysis of behavior.

Robert W Williams1, Megan K Mulligan.   

Abstract

This chapter provides an introduction into the genetic control and analysis of behavioral variation using powerful online resources. We introduce you to the new field of systems genetics using "case studies" drawn from the world of behavioral genetics that exploit populations of genetically diverse lines of mice. These lines differ very widely in patterns of gene and protein expression in the brain and in patterns of behavior. In this chapter, we address the following set of related questions: (1) Can we combine massive genomic data sets with large aggregates of precise quantitative data on behavior? (2) Can we map causal relations between gene variants and behavioral differences? (3) Can we simultaneously use these highly coherent data sets to understand more about the underlying molecular and cellular basis of behavior?
Copyright © 2012 Elsevier Inc. All rights reserved.

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Year:  2012        PMID: 23195314      PMCID: PMC4267574          DOI: 10.1016/B978-0-12-398323-7.00006-9

Source DB:  PubMed          Journal:  Int Rev Neurobiol        ISSN: 0074-7742            Impact factor:   3.230


  24 in total

1.  Genetic determinants of adult hippocampal neurogenesis correlate with acquisition, but not probe trial performance, in the water maze task.

Authors:  G Kempermann; F H Gage
Journal:  Eur J Neurosci       Date:  2002-07       Impact factor: 3.386

2.  WebQTL: rapid exploratory analysis of gene expression and genetic networks for brain and behavior.

Authors:  Elissa J Chesler; Lu Lu; Jintao Wang; Robert W Williams; Kenneth F Manly
Journal:  Nat Neurosci       Date:  2004-05       Impact factor: 24.884

3.  Genome-wide atlas of gene expression in the adult mouse brain.

Authors:  Ed S Lein; Michael J Hawrylycz; Nancy Ao; Mikael Ayres; Amy Bensinger; Amy Bernard; Andrew F Boe; Mark S Boguski; Kevin S Brockway; Emi J Byrnes; Lin Chen; Li Chen; Tsuey-Ming Chen; Mei Chi Chin; Jimmy Chong; Brian E Crook; Aneta Czaplinska; Chinh N Dang; Suvro Datta; Nick R Dee; Aimee L Desaki; Tsega Desta; Ellen Diep; Tim A Dolbeare; Matthew J Donelan; Hong-Wei Dong; Jennifer G Dougherty; Ben J Duncan; Amanda J Ebbert; Gregor Eichele; Lili K Estin; Casey Faber; Benjamin A Facer; Rick Fields; Shanna R Fischer; Tim P Fliss; Cliff Frensley; Sabrina N Gates; Katie J Glattfelder; Kevin R Halverson; Matthew R Hart; John G Hohmann; Maureen P Howell; Darren P Jeung; Rebecca A Johnson; Patrick T Karr; Reena Kawal; Jolene M Kidney; Rachel H Knapik; Chihchau L Kuan; James H Lake; Annabel R Laramee; Kirk D Larsen; Christopher Lau; Tracy A Lemon; Agnes J Liang; Ying Liu; Lon T Luong; Jesse Michaels; Judith J Morgan; Rebecca J Morgan; Marty T Mortrud; Nerick F Mosqueda; Lydia L Ng; Randy Ng; Geralyn J Orta; Caroline C Overly; Tu H Pak; Sheana E Parry; Sayan D Pathak; Owen C Pearson; Ralph B Puchalski; Zackery L Riley; Hannah R Rockett; Stephen A Rowland; Joshua J Royall; Marcos J Ruiz; Nadia R Sarno; Katherine Schaffnit; Nadiya V Shapovalova; Taz Sivisay; Clifford R Slaughterbeck; Simon C Smith; Kimberly A Smith; Bryan I Smith; Andy J Sodt; Nick N Stewart; Kenda-Ruth Stumpf; Susan M Sunkin; Madhavi Sutram; Angelene Tam; Carey D Teemer; Christina Thaller; Carol L Thompson; Lee R Varnam; Axel Visel; Ray M Whitlock; Paul E Wohnoutka; Crissa K Wolkey; Victoria Y Wong; Matthew Wood; Murat B Yaylaoglu; Rob C Young; Brian L Youngstrom; Xu Feng Yuan; Bin Zhang; Theresa A Zwingman; Allan R Jones
Journal:  Nature       Date:  2006-12-06       Impact factor: 49.962

4.  Natural variation and genetic covariance in adult hippocampal neurogenesis.

Authors:  Gerd Kempermann; Elissa J Chesler; Lu Lu; Robert W Williams; Fred H Gage
Journal:  Proc Natl Acad Sci U S A       Date:  2006-01-09       Impact factor: 11.205

5.  A transposon in Comt generates mRNA variants and causes widespread expression and behavioral differences among mice.

Authors:  Zhengsheng Li; Megan K Mulligan; Xusheng Wang; Michael F Miles; Lu Lu; Robert W Williams
Journal:  PLoS One       Date:  2010-08-17       Impact factor: 3.240

6.  GeneWeaver: a web-based system for integrative functional genomics.

Authors:  Erich J Baker; Jeremy J Jay; Jason A Bubier; Michael A Langston; Elissa J Chesler
Journal:  Nucleic Acids Res       Date:  2011-11-12       Impact factor: 16.971

7.  Complex control of GABA(A) receptor subunit mRNA expression: variation, covariation, and genetic regulation.

Authors:  Megan K Mulligan; Xusheng Wang; Adrienne L Adler; Khyobeni Mozhui; Lu Lu; Robert W Williams
Journal:  PLoS One       Date:  2012-04-10       Impact factor: 3.240

8.  A high-resolution single nucleotide polymorphism genetic map of the mouse genome.

Authors:  Sagiv Shifman; Jordana Tzenova Bell; Richard R Copley; Martin S Taylor; Robert W Williams; Richard Mott; Jonathan Flint
Journal:  PLoS Biol       Date:  2006-11       Impact factor: 8.029

9.  High-throughput behavioral phenotyping in the expanded panel of BXD recombinant inbred strains.

Authors:  V M Philip; S Duvvuru; B Gomero; T A Ansah; C D Blaha; M N Cook; K M Hamre; W R Lariviere; D B Matthews; G Mittleman; D Goldowitz; E J Chesler
Journal:  Genes Brain Behav       Date:  2009-09-22       Impact factor: 3.449

10.  Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists.

Authors:  Da Wei Huang; Brad T Sherman; Richard A Lempicki
Journal:  Nucleic Acids Res       Date:  2008-11-25       Impact factor: 16.971

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  11 in total

1.  Initial locomotor sensitivity to cocaine varies widely among inbred mouse strains.

Authors:  T Wiltshire; R B Ervin; H Duan; M A Bogue; W C Zamboni; S Cook; W Chung; F Zou; L M Tarantino
Journal:  Genes Brain Behav       Date:  2015-03       Impact factor: 3.449

2.  Progressions on the Coexistence of Neuronal and Glial Precursor Cells in the Cerebral Ventricular Zone.

Authors:  Pat Levitt
Journal:  J Neurosci       Date:  2021-02-17       Impact factor: 6.167

3.  Effects of selection for ethanol preference on gene expression in the nucleus accumbens of HS-CC mice.

Authors:  A M Colville; O D Iancu; D L Oberbeck; P Darakjian; C L Zheng; N A R Walter; C A Harrington; R P Searles; S McWeeney; R J Hitzemann
Journal:  Genes Brain Behav       Date:  2017-02-09       Impact factor: 3.449

4.  Systems Genetic Analysis in GeneNetwork.org.

Authors:  Clarissa C Parker; Price E Dickson; Vivek M Philip; Mary Thomas; Elissa J Chesler
Journal:  Curr Protoc Neurosci       Date:  2017-04-10

Review 5.  Genetics of gene expression in CNS.

Authors:  Ashutosh K Pandey; Robert W Williams
Journal:  Int Rev Neurobiol       Date:  2014       Impact factor: 3.230

6.  Genetic variation of the cutaneous HPA axis: an analysis of UVB-induced differential responses.

Authors:  Cezary Skobowiat; Reza Nejati; Lu Lu; Robert W Williams; Andrzej T Slominski
Journal:  Gene       Date:  2013-08-17       Impact factor: 3.688

7.  Systems genetic analysis of hippocampal neuroanatomy and spatial learning in mice.

Authors:  A Delprato; B Bonheur; M-P Algéo; P Rosay; L Lu; R W Williams; W E Crusio
Journal:  Genes Brain Behav       Date:  2015-11-08       Impact factor: 3.449

8.  FASTKD2 is associated with memory and hippocampal structure in older adults.

Authors:  V K Ramanan; K Nho; L Shen; S L Risacher; S Kim; B C McDonald; M R Farlow; T M Foroud; S Gao; H Soininen; I Kłoszewska; P Mecocci; M Tsolaki; B Vellas; S Lovestone; P S Aisen; R C Petersen; C R Jack; L M Shaw; J Q Trojanowski; M W Weiner; R C Green; A W Toga; P L De Jager; L Yu; D A Bennett; A J Saykin
Journal:  Mol Psychiatry       Date:  2014-11-11       Impact factor: 15.992

9.  Genetic Networks in Mouse Retinal Ganglion Cells.

Authors:  Felix L Struebing; Richard K Lee; Robert W Williams; Eldon E Geisert
Journal:  Front Genet       Date:  2016-09-28       Impact factor: 4.599

10.  A genome wide association study links glutamate receptor pathway to sporadic Creutzfeldt-Jakob disease risk.

Authors:  Pascual Sanchez-Juan; Matthew T Bishop; Gabor G Kovacs; Miguel Calero; Yurii S Aulchenko; Anna Ladogana; Alison Boyd; Victoria Lewis; Claudia Ponto; Olga Calero; Anna Poleggi; Ángel Carracedo; Sven J van der Lee; Thomas Ströbel; Fernando Rivadeneira; Albert Hofman; Stéphane Haïk; Onofre Combarros; José Berciano; Andre G Uitterlinden; Steven J Collins; Herbert Budka; Jean-Philippe Brandel; Jean Louis Laplanche; Maurizio Pocchiari; Inga Zerr; Richard S G Knight; Robert G Will; Cornelia M van Duijn
Journal:  PLoS One       Date:  2015-04-28       Impact factor: 3.240

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