| Literature DB >> 23194864 |
H Safayhi1, E R Sailer, H P Ammon.
Abstract
Acetyl-11-keto-β-boswellic acid (AKAB) from Boswellia serrata and B. carterii acts directly on purified 5-lipoxygenase of human blood leukocytes at a selective site for pentacyclic triterpenes that is different from the arachidonate substrate binding site. The pentacyclic triterpene ring is crucial for binding to the enzyme, whereas functional groups (11-keto function in addition to a hydrophilic group on C 4 of ring A) are essential for the 5-lipoxygenase activity.Entities:
Year: 1996 PMID： 23194864 DOI： 10.1016/S0944-7113(96)80013-4
Source DB: PubMed Journal: Phytomedicine ISSN： 0944-7113 Impact factor: 5.340