Literature DB >> 23194623

Inhibitory effects of the lichen metabolite lobaric acid on arachidonate metabolism in vitro.

K Ingolfsdottir1, S R Gissurarson, B Müller-Jakic, W Breu, H Wagner.   

Abstract

An extract containing phenolic constituents of the lichen Stereocaulon alpinum was shown to exhibit potent in vitro inhibitory effects on arachidonate 5-lipoxygenase from porcine leucocytes. The active component has been identified as the orcinol depsidone lobaric acid (1), which shows dose-dependent inhibitory effects on the enzyme, with an IC(50) value of 7.3 μM. Lobaric acid exhibits approximately 4-fold in vitro selectivity for 5-lipoxygenase as compared to cyclooxygenase.
Copyright © 1996 Gustav Fischer Verlag, Stuttgart · Jena · New York. Published by Elsevier GmbH.. All rights reserved.

Entities:  

Year:  1996        PMID： 23194623     DOI： 10.1016/S0944-7113(96)80049-3

Source DB:  PubMed          Journal:  Phytomedicine        ISSN： 0944-7113            Impact factor:   5.340


  4 in total

1.  α-Pyrone and Sterol Constituents of Penicillium aurantiacobrunneum, a Fungal Associate of the Lichen Niebla homalea.

Authors:  Choon Yong Tan; Fengrui Wang; Gerardo D Anaya-Eugenio; Judith C Gallucci; Kristie D Goughenour; Chad A Rappleye; Richard W Spjut; Esperanza J Carcache de Blanco; A Douglas Kinghorn; L Harinantenaina Rakotondraibe
Journal:  J Nat Prod       Date:  2019-08-29       Impact factor: 4.050

2.  Depsides: lichen metabolites active against hepatitis C virus.

Authors:  Thi Huyen Vu; Anne-Cécile Le Lamer; Claudia Lalli; Joël Boustie; Michel Samson; Françoise Lohézic-Le Dévéhat; Jacques Le Seyec
Journal:  PLoS One       Date:  2015-03-20       Impact factor: 3.240

3.  Lobaric Acid Inhibits VCAM-1 Expression in TNF-α-Stimulated Vascular Smooth Muscle Cells via Modulation of NF-κB and MAPK Signaling Pathways.

Authors:  Ii-Seul Kwon; Joung-Han Yim; Hong-Kum Lee; Suhkneung Pyo
Journal:  Biomol Ther (Seoul)       Date:  2016-01-01       Impact factor: 4.634

4.  Imbricaric acid and perlatolic acid: multi-targeting anti-inflammatory depsides from Cetrelia monachorum.

Authors:  Sarah K Oettl; Jana Gerstmeier; Shafaat Y Khan; Katja Wiechmann; Julia Bauer; Atanas G Atanasov; Clemens Malainer; Ezzat M Awad; Pavel Uhrin; Elke H Heiss; Birgit Waltenberger; Daniel Remias; Johannes M Breuss; Joel Boustie; Verena M Dirsch; Hermann Stuppner; Oliver Werz; Judith M Rollinger
Journal:  PLoS One       Date:  2013-10-09       Impact factor: 3.240
  4 in total

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