| Literature DB >> 23194425 |
Verena Pichler1, Petra Heffeter, Seied M Valiahdi, Christian R Kowol, Alexander Egger, Walter Berger, Michael A Jakupec, Mathea Sophia Galanski, Bernhard K Keppler.
Abstract
Eight novel mononuclear and two dinuclear platinum(IV) complexes were synthesized and characterized by elemental analysis, one- and two-dimensional NMR spectroscopy, mass spectrometry, and reversed-phase HPLC (log k(w)) and in one case by X-ray diffraction. Cytotoxicity of the compounds was studied in three human cancer cell lines (CH1, SW480, and A549) by means of the MTT assay, featuring IC(50) values to the low micromolar range. Furthermore a selected set of compounds was investigated in additional cancer cell lines (P31 and P31/cis, A2780 and A2780/cis, SW1573, 2R120, and 2R160) with regard to their resistance patterns, offering a distinctly different scheme compared to cisplatin. To gain further insights into the mode of action, drug uptake, DNA synthesis inhibition, cell cycle effects, and induction of apoptosis were determined for two characteristic substances.Entities:
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Year: 2012 PMID： 23194425 PMCID： PMC4021451 DOI： 10.1021/jm301645g
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446