Literature DB >> 23189988

PPAR-γ agonistic metabolites from the ascidian Herdmania momus.

Jian Lin Li1, Bin Xiao, Minhi Park, Eun Sook Yoo, Sook Shin, Jongki Hong, Hae Young Chung, Hyung Sik Kim, Jee H Jung.   

Abstract

Seven new amino acid derivatives (1-4 and 6-8) were isolated from MeOH extracts of the marine ascidian Herdmania momus. Planar structures were established on the basis of NMR, IR, and MS spectroscopic analyses. Absolute configurations of these compounds were derived from specific rotation and CD analysis. The peroxisome proliferator-activated receptor (PPAR)-γ agonistic activities of the compounds were investigated due to the similarity of the structural motif to that of the antidiabetic drug rosiglitazone. Analogues with indoleglyoxyl moieties (5, 6, and 8) showed significant PPAR-γ activation in Ac2F rat liver cells.

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Year:  2012        PMID： 23189988     DOI： 10.1021/np300401g

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  8 in total

Review 1.  Biological Activity of Recently Discovered Halogenated Marine Natural Products.

Authors:  Gordon W Gribble
Journal:  Mar Drugs       Date:  2015-06-30       Impact factor: 5.118

Review 2.  Natural Products Diversity of Marine Ascidians (Tunicates; Ascidiacea) and Successful Drugs in Clinical Development.

Authors:  Satheesh Kumar Palanisamy; N M Rajendran; Angela Marino
Journal:  Nat Prod Bioprospect       Date:  2017-01-17

Review 3.  Marine Pharmacology in 2012-2013: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis, and Antiviral Activities; Affecting the Immune and Nervous Systems, and Other Miscellaneous Mechanisms of Action.

Authors:  Alejandro M S Mayer; Abimael D Rodríguez; Orazio Taglialatela-Scafati; Nobuhiro Fusetani
Journal:  Mar Drugs       Date:  2017-08-29       Impact factor: 5.118

4.  N-Methyl-β-carbolinium Salts and an N-Methylated 8-Oxoisoguanine as Acetylcholinesterase Inhibitors from a Solitary Ascidian, Cnemidocarpa irene.

Authors:  Yohei Tadokoro; Teruaki Nishikawa; Taichi Ichimori; Satoko Matsunaga; Masaki J Fujita; Ryuichi Sakai
Journal:  ACS Omega       Date:  2017-03-21

Review 5.  Marine Indole Alkaloids.

Authors:  Natalie Netz; Till Opatz
Journal:  Mar Drugs       Date:  2015-08-06       Impact factor: 5.118

Review 6.  Targeting nuclear receptors with marine natural products.

Authors:  Chunyan Yang; Qianrong Li; Yong Li
Journal:  Mar Drugs       Date:  2014-01-27       Impact factor: 5.118

7.  Epimeric methylsulfinyladenosine derivatives from the marine ascidian Herdmania momus.

Authors:  Jian Lin Li; Eun La Kim; Haibo Wang; Jongki Hong; Sook Shin; Chong-Kyo Lee; Jee H Jung
Journal:  Bioorg Med Chem Lett       Date:  2013-06-07       Impact factor: 2.823

Review 8.  Origins and Bioactivities of Natural Compounds Derived from Marine Ascidians and Their Symbionts.

Authors:  Xiaoju Dou; Bo Dong
Journal:  Mar Drugs       Date:  2019-11-28       Impact factor: 5.118
  8 in total

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