BACKGROUND: Plasminogen activator inhibitor (PAI)-2 was previously shown to be less frequently expressed in hepatocellular carcinoma (HCC). The present study was designed to investigate the clinical, pathological, and prognostic significance of PAI-2 expression in HCC. METHODS: Expression of PAI-2 was detected immunohistochemically for specimens from 78 patients with HCC after hepatic resection and correlated with clinicopathological features and patient survival. Risk factors of portal vein tumor thrombosis (PVTT) were also analyzed. RESULTS: Positive PAI-2 staining was observed in tumor and non-tumor tissues from 21 (26.9%) and 56 (71.8%) patients, respectively. Plasminogen activator inhibitor-2 negativity in tumor tissues was significantly associated with PVTT, with a high sensitivity not only in univariate analysis but also in multivariate analysis. In addition, positive PAI-2 staining was related to smaller tumor size and prolonged patient survival. The Cox regression model identified intratumoral PAI-2 staining as an independent prognosticator in patients with HCC after resection. CONCLUSIONS: Our data demonstrated that low expression of PAI-2 serves as a novel marker of PVTT and poor prognosis in HCC.
BACKGROUND:Plasminogen activator inhibitor (PAI)-2 was previously shown to be less frequently expressed in hepatocellular carcinoma (HCC). The present study was designed to investigate the clinical, pathological, and prognostic significance of PAI-2 expression in HCC. METHODS: Expression of PAI-2 was detected immunohistochemically for specimens from 78 patients with HCC after hepatic resection and correlated with clinicopathological features and patient survival. Risk factors of portal vein tumor thrombosis (PVTT) were also analyzed. RESULTS: Positive PAI-2 staining was observed in tumor and non-tumor tissues from 21 (26.9%) and 56 (71.8%) patients, respectively. Plasminogen activator inhibitor-2 negativity in tumor tissues was significantly associated with PVTT, with a high sensitivity not only in univariate analysis but also in multivariate analysis. In addition, positive PAI-2 staining was related to smaller tumor size and prolonged patient survival. The Cox regression model identified intratumoral PAI-2 staining as an independent prognosticator in patients with HCC after resection. CONCLUSIONS: Our data demonstrated that low expression of PAI-2 serves as a novel marker of PVTT and poor prognosis in HCC.
Authors: Pierre Champelovier; Nathalie Boucard; Geraldine Levacher; Annick Simon; Daniel Seigneurin; Vincent Praloran Journal: Urol Res Date: 2002-08-15
Authors: T Wang; H S Hu; Y X Feng; J Shi; N Li; W X Guo; J Xue; D Xie; S R Liu; M C Wu; S Q Cheng Journal: Br J Cancer Date: 2010-05-11 Impact factor: 7.640
Authors: Grant A Darnell; Toni M Antalis; Ricky W Johnstone; Brett W Stringer; Steven M Ogbourne; David Harrich; Andreas Suhrbier Journal: Mol Cell Biol Date: 2003-09 Impact factor: 4.272
Authors: Marion E Meijer-van Gelder; Maxime P Look; Harry A Peters; Manfred Schmitt; Nils Brünner; Nadia Harbeck; Jan G M Klijn; John A Foekens Journal: Cancer Res Date: 2004-07-01 Impact factor: 12.701
Authors: Nathalie Wong; Winnie Yeo; Wai-Lap Wong; Navy L-Y Wong; Kathy Y-Y Chan; Frankie K-F Mo; Jane Koh; Stephan Lam Chan; Anthony T-C Chan; Paul B-S Lai; Arthur K-K Ching; Joanna H-M Tong; Ho-Keung Ng; Philip J Johnson; Ka-Fai To Journal: Int J Cancer Date: 2009-02-01 Impact factor: 7.396