| Literature DB >> 23188057 |
Jun Wu1, Rong Huang, Changcheng Wang, Wenting Liu, Jiaqi Wang, Xiaocheng Weng, Tian Tian, Xiang Zhou.
Abstract
A new bifunctional compound NCC, which undergoes thiol-mediated disulfide cleavage after cell entry, produces a red-shifted fluorescent emission in the cytosol and releases free active DNA alkylating agent CLB into the nucleus, and finally leads to DNA damage and cell death.Entities:
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Year: 2012 PMID： 23188057 DOI： 10.1039/c2ob26680f
Source DB: PubMed Journal: Org Biomol Chem ISSN： 1477-0520 Impact factor: 3.876