Literature DB >> 23187136

αKlotho: FGF23 coreceptor and FGF23-regulating hormone.

Harald Jüppner1, Myles Wolf.   

Abstract

Low levels of phosphate can disrupt bone ossification and predispose to fractures. FGF23 is one of the major determinants of phosphate homeostasis, acting to increase urinary phosphate excretion. However, the regulation of FGF23 is incompletely understood. In this issue of the JCI, Smith et al. show that the cleaved form of αKlotho, the membrane-bound form of which is an FGF23 coreceptor, serves as a novel endocrine regulator of phosphate homeostasis, capable of inducing FGF23 production in osteocytes.

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Year:  2012        PMID： 23187136      PMCID： PMC3533569          DOI： 10.1172/JCI67055

Source DB:  PubMed          Journal:  J Clin Invest        ISSN： 0021-9738            Impact factor:   14.808


  21 in total

1.  Klotho: a novel phosphaturic substance acting as an autocrine enzyme in the renal proximal tubule.

Authors:  Ming Chang Hu; Mingjun Shi; Jianning Zhang; Johanne Pastor; Teruyo Nakatani; Beate Lanske; M Shawkat Razzaque; Kevin P Rosenblatt; Michel G Baum; Makoto Kuro-o; Orson W Moe
Journal:  FASEB J       Date:  2010-05-13       Impact factor: 5.191

2.  Iron deficiency drives an autosomal dominant hypophosphatemic rickets (ADHR) phenotype in fibroblast growth factor-23 (Fgf23) knock-in mice.

Authors:  Emily G Farrow; Xijie Yu; Lelia J Summers; Siobhan I Davis; James C Fleet; Matthew R Allen; Alexander G Robling; Keith R Stayrook; Victoria Jideonwo; Martin J Magers; Holly J Garringer; Ruben Vidal; Rebecca J Chan; Charles B Goodwin; Siu L Hui; Munro Peacock; Kenneth E White
Journal:  Proc Natl Acad Sci U S A       Date:  2011-10-17       Impact factor: 11.205

Review 3.  Regulation and function of the FGF23/klotho endocrine pathways.

Authors:  Aline Martin; Valentin David; L Darryl Quarles
Journal:  Physiol Rev       Date:  2012-01       Impact factor: 37.312

4.  Initial FGF23-mediated signaling occurs in the distal convoluted tubule.

Authors:  Emily G Farrow; Siobhan I Davis; Lelia J Summers; Kenneth E White
Journal:  J Am Soc Nephrol       Date:  2009-04-08       Impact factor: 10.121

5.  Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism.

Authors:  Takashi Shimada; Makoto Kakitani; Yuji Yamazaki; Hisashi Hasegawa; Yasuhiro Takeuchi; Toshiro Fujita; Seiji Fukumoto; Kazuma Tomizuka; Takeyoshi Yamashita
Journal:  J Clin Invest       Date:  2004-02       Impact factor: 14.808

6.  A translocation causing increased alpha-klotho level results in hypophosphatemic rickets and hyperparathyroidism.

Authors:  Catherine A Brownstein; Felix Adler; Carol Nelson-Williams; Junko Iijima; Peining Li; Akihiro Imura; Yo-Ichi Nabeshima; Miguel Reyes-Mugica; Thomas O Carpenter; Richard P Lifton
Journal:  Proc Natl Acad Sci U S A       Date:  2008-02-28       Impact factor: 11.205

7.  Circulating αKlotho influences phosphate handling by controlling FGF23 production.

Authors:  Rosamund C Smith; Linda M O'Bryan; Emily G Farrow; Lelia J Summers; Erica L Clinkenbeard; Jessica L Roberts; Taryn A Cass; Joy Saha; Carol Broderick; Y Linda Ma; Qing Qiang Zeng; Alexei Kharitonenkov; Jonathan M Wilson; Qianxu Guo; Haijun Sun; Matthew R Allen; David B Burr; Matthew D Breyer; Kenneth E White
Journal:  J Clin Invest       Date:  2012-11-26       Impact factor: 14.808

Review 8.  Update on fibroblast growth factor 23 in chronic kidney disease.

Authors:  Myles Wolf
Journal:  Kidney Int       Date:  2012-05-23       Impact factor: 10.612

Review 9.  The amazing osteocyte.

Authors:  Lynda F Bonewald
Journal:  J Bone Miner Res       Date:  2011-02       Impact factor: 6.741

10.  FGF-23: More than a regulator of renal phosphate handling?

Authors:  Harald Jüppner; Myles Wolf; Isidro B Salusky
Journal:  J Bone Miner Res       Date:  2010-10       Impact factor: 6.741
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  3 in total

Review 1.  FGF-23 and secondary hyperparathyroidism in chronic kidney disease.

Authors:  Justin Silver; Tally Naveh-Many
Journal:  Nat Rev Nephrol       Date:  2013-07-23       Impact factor: 28.314

2.  NFκB-sensitive Orai1 expression in the regulation of FGF23 release.

Authors:  Bingbing Zhang; Jing Yan; Anja T Umbach; Hajar Fakhri; Abul Fajol; Sebastian Schmidt; Madhuri S Salker; Hong Chen; Dorothea Alexander; Daniela Spichtig; Arezoo Daryadel; Carsten A Wagner; Michael Föller; Florian Lang
Journal:  J Mol Med (Berl)       Date:  2015-12-03       Impact factor: 4.599

3.  Potential Predictors of Plasma Fibroblast Growth Factor 23 Concentrations: Cross-Sectional Analysis in the EPIC-Germany Study.

Authors:  Romina di Giuseppe; Tilman Kühn; Frank Hirche; Brian Buijsse; Jutta Dierkes; Andreas Fritsche; Rudolf Kaaks; Heiner Boeing; Gabriele I Stangl; Cornelia Weikert
Journal:  PLoS One       Date:  2015-07-20       Impact factor: 3.240
  3 in total

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