Fabrication of novel 3D nanofiber scaffolds with anisotropic property and regular pores and their potential applications.

A new and simple approach for preparing 3D nanofiber scaffolds in a basket-weaved structure composed of uniaxially aligned, electrospun nanofiber strips is reported. It is also demonstrated that human adipose-derived stem cells seeded are distributed uniformly throughout different layers of scaffolds and can proliferate and be organized by the nanotopographic cues imparted by uniaxial arrays of nanofiber.